Multiregional Tumor Trees Are Not Phylogenies.

Multiregional Tumor Trees Are Not Phylogenies.
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DOI:
10.1016/j.trecan.2017.06.004
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发表时间:
2017-08
期刊:
影响因子:
18.4
通讯作者:
Posada D
Posada D
中科院分区:
医学1区
文献类型:
--
作者:
Alves JM;Prieto T;Posada D

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肿瘤样品通常包含不同细胞谱系的混合物。从大量突变谱构建的多区域树没有考虑这种异质性,并且可能导致错误的进化推论,包括体细胞突变的时间偏差、虚假的平行突变事件和/或转移事件的不正确的时间顺序。
Tumor samples most often comprise a mixture of different cell lineages. Multiregional trees built from bulk mutational profiles do not consider this heterogeneity and can potentially lead to erroneous evolutionary inferences, including biased timing of somatic mutations, spurious parallel mutation events, and/or incorrect chronological ordering of metastatic events.
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