Improved spatial characterization of the epileptic brain by focusing on nonlinearity
Improved spatial characterization of the epileptic brain by focusing on nonlinearity
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DOI：
10.1016/j.eplepsyres.2005.12.004
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发表时间：
2006-04-01
影响因子：
2.2
通讯作者：
Lehnertz, K
中科院分区：
文献类型：
--
作者：
Andrzejak, RG;Mormann, F;Lehnertz, K
对复杂的大脑动力系统进行高级表征是科学界面临的最大挑战之一。非线性时间序列分析允许表征非线性动力系统，其中低维非线性引起复杂和不规则的行为。虽然一些研究表明非线性方法可以从神经元动力学中提取有价值的信息，但其他人怀疑其必要性，并推测使用经典线性技术可以获得相同的信息。为了解决这个问题，我们比较了这两个概念，但进一步包括非线性测量与替代品的组合，这是一种专门针对非线性的方法。作为基准，我们使用判别能力检测难治性内侧颞叶癫痫的发作半球。我们分析了29例患者无癫痫发作期间的颅内脑电图记录。虽然线性和非线性测量的性能都很弱，如果不是微不足道的话，但通过使用替代校正的测量获得了非常高的性能。通过使用非线性测量与替代物的结合来关注非线性似乎是成功表征癫痫过程空间分布的关键。(c) 2006 Elsevier B.V.版权所有
An advanced characterization of the complicated dynamical system brain is one of science's biggest challenges. Nonlinear time series analysis allows characterizing nonlinear dynamical systems in which low-dimensional nonlinearity gives rise to complex and irregular behavior. While several studies indicate that nonlinear methods can extract valuable information from neuronal dynamics, others doubt their necessity and conjecture that the same information can be obtained using classical linear techniques. To address this issue, we compared these two concepts, but included furthermore a combination of nonlinear measures with surrogates, an approach that has been designed to specifically focus on nonlinearity. As a benchmark we used the discriminative power to detect the seizure-generating hemisphere in medically intractable mesial temporal lobe epilepsy. We analyzed intracranial electroencephalographic recordings from the seizure-free interval of 29 patients. While the performance of both linear and nonlinear measures was weak, if not insignificant, a very high performance was obtained by the use of surrogate-corrected measures. Focusing on nonlinearity by using a combination of nonlinear measures with surrogates appears as the key to a successful characterization of the spatial distribution of the epileptic process. (c) 2006 Elsevier B.V. All rights reserved.