The roles of sex, race, and ABO groups.
The roles of sex, race, and ABO groups.
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性别、种族和 ABO 群体的角色。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Cecka
中科院分区：
文献类型：
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作者：
J. Cecka
1.性别差异在移植结果中没有显著作用。2.在最近的移植中，供体性别出人意料地成为一个主要因素。环孢霉素并没有增加年龄在31岁至50岁之间的女性供体肾的移植存活率，高于常规免疫抑制所达到的存活率。在首次尸体肾移植中，男性肾的一年存活率比女性肾高7%，在接受环孢素治疗的再次移植受体中，一年存活率高13%。3.女性供肾在环孢素治疗的患者中早期功能率较差。第一天的无功能率为27%的第一尸体受体的女性供体肾和19%的男性供体肾。在移植后早期肾脏功能不全的受者中，女性供体移植物的受者的平均血清肌酐水平高于男性供体移植物的受者。4.女性尸体供肾的存活率和早期功能率也受到首次移植受者供体年龄的影响。30岁以下女性的肾脏和男性供体的肾脏都存活了下来，这表明这种影响与性别无关。5. HLA-A、B抗原匹配消除了供体性别的影响。在首次尸体、尸体再移植和活体亲属供肾移植中，供肾和受体之间没有HLA-A、B抗原错配时，移植肾存活率对于男性和女性是相同的。HLA-A、B的错配使女性供者移植物的存活率在一年内降低了25%，而男性供者移植物的存活率则低得多。6.首次尸体供体移植的黑人受体移植物存活率明显低于白色受体。尽管环孢素改善了黑人移植物存活率，但黑人受体和白色受体移植物存活率之间仍有10%的差异。7.虽然移植的数量很少，但在使用环孢素时，用尸体供体肾重新移植或接受活体亲属供体移植的黑人中没有明显的种族效应。8.黑人供肾移植给白色受者的移植物存活率低，部分原因是HLA配型非常差。9.在接受环孢素治疗的受者中，黑色供体肾与老年女性供体肾表现出惊人的相似性。环孢素肾毒性或排斥反应可能与高血压供体的肾脏有关。10.在最近的移植中，不同血型的受体之间移植物存活率没有差异。（400字处截断摘要）
1. Recipient sex did not play a significant role in transplant outcome. 2. Donor sex emerged as a surprisingly major factor in recent transplants. Cyclosporine did not increase graft survival of female donor kidneys from donors between the ages of 31 and 50 above survival rates achieved by conventional immunosuppression. Male kidneys had a 7% higher one-year survival rate than female kidneys in first cadaver transplants and a 13% higher one-year survival rate in regraft recipients treated with cyclosporine. 3. Female donor kidneys had poorer early function rates in cyclosporine-treated patients. The first day nonfunction rate was 27% in first cadaver recipients of female donor kidneys and 19% for male donor kidneys. Among recipients whose kidneys did not function in the early posttransplant period, recipients of female donor grafts had higher average serum creatinine levels than recipients of male donor grafts. 4. The poorer survival and early function rates of female cadaver donor kidneys were also affected by the age of the donor in first transplant recipients. Kidneys from females less than 30 years old survived as well as male donor kidneys, suggesting that the effect was not strictly sex-associated. 5. Matching for HLA-A,B antigens abrogated the effect of donor sex. Graft survival was the same for both male and female kidneys when no HLA-A,B antigens were mismatched between the donor and recipient in first cadaver, cadaver regraft, and living-related donor transplants. Mismatches at HLA-A,B reduced survival of female donor grafts in patients who were retransplanted by as much as 25% at one year, while male donor grafts were much less affected. 6. Black recipients had significantly lower graft survival rates than white recipients of first cadaver donor transplants. Although cyclosporine improved graft survival in blacks, there remained a 10% discrepancy between the survival of transplants in black recipients and in white recipients. 7. Although the number of transplants was small, there was no apparent race effect in blacks who were retransplanted with a cadaver donor kidney or who received a transplant from a living related donor when cyclosporine was used. 8. The poor graft survival of black donor kidneys transplanted to white recipients was due in part to very poor HLA matching. 9. The black donor kidney showed a striking similarity to the older female donor kidney in recipients treated with cyclosporine. There may be an association between cyclosporine nephrotoxicity or rejection and kidneys from hypertensive donors. 10. There were no differences in graft survival between recipients of the various blood types in recent transplants.(ABSTRACT TRUNCATED AT 400 WORDS)