Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba
Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba
复制标题
来自海洋海绵 Haliclona crassiloba 的生物活性多羟基甾醇
DOI：
10.1016/j.steroids.2013.10.004
复制
发表时间：
2013-12-20
期刊：
影响因子：
2.7
通讯作者：
Yin, Sheng
中科院分区：
文献类型：
--
作者：
Cheng, Zhong-Bin;Xiao, Han;Yin, Sheng
从海绵Haliclona crassiloba中分离得到4个新的多羟基甾醇化合物，命名为Halicrasterol A-D(1-4)和6个已知类似物(5-10)。化合物1和2是具有17(20)E-双键的甾体的罕见例子。通过波谱分析和与文献数据的比较，确定了1-10的结构。这是该物种类固醇分布的第一次报告。化合物1-10对一组细菌和真菌菌株的体外抑菌活性进行了评价，化合物4和9对部分革兰氏阳性菌株表现出中等活性，最低抑菌浓度(MIC)在4~32mU g/mL之间。(C)2013爱思唯尔有限公司。保留所有权利。
Four new polyhydroxylated sterols, named halicrasterols A-D (1-4), together with six known analogs (5-10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1-10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1-10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.