Imidacloprid, a Neonicotinoid Insecticide, Potentiates Adipogenesis in 3T3-L1 Adipocytes
Imidacloprid, a Neonicotinoid Insecticide, Potentiates Adipogenesis in 3T3-L1 Adipocytes
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DOI：
10.1021/jf3039814
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发表时间：
2013-01-09
影响因子：
6.1
通讯作者：
Park, Yeonhwa
中科院分区：
文献类型：
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作者：
Park, Yooheon;Kim, Younghwa;Park, Yeonhwa
越来越多的证据表明，接触有机氯和有机磷杀虫剂可能与体重过度增加和糖尿病症状有关。然而，对其他类型的杀虫剂对肥胖和糖尿病有潜在影响的知识缺乏。因此，本研究的目的是确定咪唑多巴（一种新烟碱类杀虫剂）通过3T3-L1脂肪细胞在脂质代谢中的作用。吡虫啉增强了3T3-L1脂肪细胞的脂质积累，显著增加了脂肪细胞分化和脂肪生成关键调节因子的表达。这些结果暗示吡虫啉参与改变脂肪生成，导致脂肪堆积增加。这一发现是首次报道新烟碱类杀虫剂暴露与脂肪细胞中脂质积累之间的潜在联系。在我们能够推断吡虫啉对人类肥胖的潜在作用之前，还需要进一步的体内和流行病学研究。
There is emerging evidence that organochlorine and organophosphorus insecticide exposure may be linked to excessive weight gain and symptoms of diabetes. However, there is a lack of knowledge for other types of insecticides with potential influence on obesity and diabetes. Thus, the purpose of this investigation was to determine the role of imidadoprid, a neonicotinoid insecticide, in lipid metabolism by use of 3T3-L1 adipocytes. Imidacloprid treatment potentiated lipid accumulation in 3T3-L1 adipocytes and significantly increased expression of a key regulator of adipocyte differentiation and key regulators of lipogenesis. These results imply the involvement of imidacloprid in altered adipogenesis, resulting in increased fat accumulation. This finding is the first report of a potential link between neonicotinoid insecticide exposure and lipid accumulation in adipocytes. Further in vivo as well as epidemiological studies will be required before we can extrapolate these findings to a potential contribution of imidacloprid in human obesity.