Gender differences in cognitive function of patients with chronic schizophrenia
Gender differences in cognitive function of patients with chronic schizophrenia
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DOI：
10.1016/j.pnpbp.2012.07.010
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发表时间：
2012-12-03
影响因子：
5.6
通讯作者：
Zhang, Xiang Yang
中科院分区：
文献类型：
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作者：
Han, Mei;Huang, Xu-Feng;Zhang, Xiang Yang
精神分裂症患者存在认知障碍，但对这些认知障碍的性别差异的研究有限。本研究评估了471名受试者的认知功能，其中包括122名男性和78名女性精神分裂症患者以及141名男性和130名女性健康对照。我们发现，即时记忆，语言，延迟记忆和总的RBANS分数显着降低精神分裂症与健康对照组的两种性别。男性患者的即时记忆、延迟记忆和RBANS总分显著低于女性患者，健康对照组显示出类似的性别差异。RBANS与PANSS评分、病程和抗精神病药物剂量（氯丙嗪当量）呈中度相关。精神分裂症患者和健康对照组的RBANS得分几乎都与受教育程度呈显著正相关。因此，精神分裂症患者的性别经历了更多的恶化性能比健康对照组的认知领域的即时记忆，语言和延迟记忆。此外，男性精神分裂症患者在即时记忆和延迟记忆方面的认知障碍比女性患者严重，但在语言、视觉空间和注意力指标方面没有显著差异。(C)2012 Elsevier Inc. All rights reserved.
Schizophrenic patients have cognitive impairments, but gender differences in these cognitive deficits have had limited study. This study assessed cognitive functioning in 471 subjects including 122 male and 78 female schizophrenic patients and 141 male and 130 female healthy controls. We found that immediate memory, language, delayed memory and total RBANS scores were significantly decreased in schizophrenia compared with healthy controls for both genders. Male patients had significant lower immediate memory, delayed memory and total RBANS scores than female patients, and healthy controls showed a similar gender difference. The RBANS showed modest correlations with PANSS scores, duration of illness and antipsychotic dose (chlorpromazine equivalents). Almost all RBANS scores in the schizophrenics and healthy controls showed significant positive correlations with education. Thus, patients of both sexes with schizophrenia experienced more deteriorated performance than healthy controls on cognitive domains of immediate memory, language and delayed memory. Furthermore, male schizophrenic patients had more serious cognitive deficits than female patients in immediate and delayed memory, but not in language, visuospatial and attention indices. (C) 2012 Elsevier Inc. All rights reserved.