CLINICAL EFFICACY OF SPONDYVIT (VITAMIN-E) IN ACTIVATED ARTHROSES - A MULTICENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY
CLINICAL EFFICACY OF SPONDYVIT (VITAMIN-E) IN ACTIVATED ARTHROSES - A MULTICENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY
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DOI：
10.1055/s-2008-1044572
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发表时间：
1986-05-01
期刊：
影响因子：
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通讯作者：
BLANKENHORN, G
中科院分区：
文献类型：
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作者：
BLANKENHORN, G
[50]骨性关节炎患者随机分为两组，服用维生素e胶囊（每日剂量400 I.E. d-. α）治疗6周。-生育酚乙酸酯)或相同的安慰剂制剂。本双盲对照临床试验结果显示，维生素E在缓解疼痛（静止疼痛、运动疼痛、压力性疼痛）和额外镇痛治疗的必要性方面优于安慰剂（p < 0.05 ~ p < 0.01）。维生素e组的活动能力改善更好，但这一结果没有统计学意义。维生素E组和安慰剂组的不良反应的特征和强度几乎相同。本临床研究显示维生素E对骨关节炎患者有抗炎作用。鉴于有可能减少标准的抗炎、镇痛治疗，加上很好的耐受性，这一结果可能对慢性风湿性炎症疾病的治疗非常重要。
Patients [50] with osteoarthritis were randomly assigned to two groups and treated over a period of 6 weeks with vitamin E-capsules (daily dose 400 I.E. d-.alpha.-tocopherylacetate) or an identical placebo preparation. The results of this double-blind controlled clinical trial showed that vitamin E was superior to placebo with respect to the relief of pain (pain at rest, pain during movement, pressure-induced pain) and the necessity of additional analgetic treatment (p < 0.05 to p < 0.01). Improvement of mobility was better in the group treated with vitamin E. However, this result was not statistically significant. The profile and the intensity of adverse reactions in both the vitamin E and placebo group was practically identical. This clinical study shows antiphlogistic efficacy of vitamin E in patients with osteoarthritis. In view of the possibility to reduce standard antiphlogistic, analgetic therapy together with the very good tolerance this result may be very important for the treatment of chronic rheumatic inflammatory disease.