Axonal sprouts containing calcitonin gene-related peptide and substance P form pericellular baskets around large diameter neurons after sciatic nerve transection in the rat
Axonal sprouts containing calcitonin gene-related peptide and substance P form pericellular baskets around large diameter neurons after sciatic nerve transection in the rat
复制标题
大鼠坐骨神经横断后，含有降钙素基因相关肽和 P 物质的轴突芽在大直径神经元周围形成细胞周篮
DOI：
10.1016/s0306-4522(97)00680-5
复制
发表时间：
1998
期刊：
影响因子：
3.3
通讯作者：
P. Hu
中科院分区：
文献类型：
--
作者：
E. McLachlan;P. Hu
外周神经损伤后，在病变近端发生解剖重构，包括血管周围轴突的萌发，在含有受损神经元的背根神经节大直径初级传入体周围形成去肾上腺素能终端篮（“环”）11,15，以及终止于背角深处的a β轴突的萌发11.19，这些异常的结构关联可能导致感觉加工的改变，从而导致神经性疼痛。交感神经轴突萌发的触发因素可能是局部集中的神经营养因子（如神经生长因子）。14,20神经生长因子信使RNA已知在坐骨神经横断后背根神经节中增加18，局部神经生长因子的增加引起完整的交感神经末梢侧支萌发到邻近的无神经支配的皮肤。3,5含有降钙素基因相关肽的伤害性末梢，不论是否含有P物质，也会随着神经生长因子浓度的升高而萌发。我们发现，在坐骨神经横断后，成年大鼠大直径背根神经节细胞周围的小感觉神经元轴突对这些肽具有免疫反应，与此同时，去甲肾上腺素能末梢的环也在发育
Trauma to a peripheral nerve is followed by anatomical remodelling proximal to the lesion, including sprouting of perivascular axons to form baskets of noradrenergic terminals (“rings”) around large diameter primary afferent somata in the dorsal root ganglia containing lesioned neurons11,15and sprouting of Aβ axons terminating deep in the dorsal horn into Lamina 11.19These abnormal structural associations may contribute to the changes in sensory processing that lead to neuropathic pain. The trigger for sprouting of sympathetic axons is probably a neurotrophin (such as nerve growth factor) concentrated locally.14,20Nerve growth factor messenger RNA is known to be increased in dorsal root ganglia after sciatic nerve transection18and increased local nerve growth factor elicits collateral sprouting of intact sympathetic terminals into adjacent denervated skin.3,5Nociceptive terminals containing calcitonin gene-related peptide, with or without substance P,6also sprout in response to raised concentrations of nerve growth factor.3We have found that axons of small sensory neurons immunoreactive for these peptides also form rings around large diameter dorsal root ganglion cells of adult rats after sciatic nerve transection, concurrently with the development of rings of noradrenergic terminals.11