Umbilical cord leptin predicts neonatal bone mass
Umbilical cord leptin predicts neonatal bone mass
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DOI：
10.1007/s00223-004-1128-3
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发表时间：
2005-05-01
影响因子：
4.2
通讯作者：
Cooper, C
中科院分区：
文献类型：
--
作者：
Javaid, MK;Godfrey, KM;Cooper, C
越来越多的证据表明，晚年骨质疏松症的风险可能部分取决于宫内和产后早期生活中对骨骼发育的环境影响。动物研究表明，胎儿瘦素在介导这些作用中的潜在作用表明，瘦素影响产前成骨细胞的生长和发育，胎儿瘦素浓度会因母体营养的变化而改变。在一组足月人类婴儿中，我们之前报道过母亲出生体重、吸烟、脂肪量和妊娠后期的运动独立预测新生儿骨量。为了研究瘦素在介导这些影响中的潜在作用，我们现在将117名婴儿的脐静脉血清中瘦素浓度与新生儿骨量和身体成分联系起来。脐静脉瘦素浓度与全身骨矿物质含量（BMC）呈显著正相关(r = 0.42， P
Evidence is accumulating that the risk of osteoporosis in later life may be determined in part by environmental influences on bone development during intrauterine and early postnatal life. A potential role for fetal leptin in mediating these effects is suggested by animal studies showing that leptin influences prenatal osteoblast growth and development, and that fetal leptin concentrations are altered by changes in maternal nutrition. In a group of term human infants we reported previously that maternal birthweight, smoking, fat mass, and exercise during late pregnancy independently predict neonatal bone mass. To investigate the potential role of leptin in mediating these effects, we now relate leptin concentrations in umbilical venous serum to neonatal bone mass and body composition in 117 infants. There were strong positive associations between umbilical venous leptin concentration and each of whole body bone mineral contents (BMC) (r = 0.42, P