Epidemiological, clinical, and laboratory characteristics of 48 cases of "Babesia venatorum" infection in China: a descriptive study
Epidemiological, clinical, and laboratory characteristics of 48 cases of "Babesia venatorum" infection in China: a descriptive study
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中国48例“猎性巴贝斯虫”感染的流行病学、临床和实验室特征：描述性研究
DOI：
10.1016/s1473-3099(14)71046-1
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发表时间：
2015-02-01
影响因子：
56.3
通讯作者：
Cao, Wu-Chun
中科院分区：
文献类型：
--
作者：
Jiang, Jia-Fu;Zheng, Yuan-Chun;Cao, Wu-Chun
背景人巴贝斯虫病是一种新出现的人畜共患病。到目前为止，只有四名脾功能不全的男子和一名儿童被确认患有“脉络巴贝斯虫”。目的描述黑龙江省牡丹江市林区中心医院发现的一系列“B静脉”感染病例的流行病学、临床和实验室特征。这些病例通过聚合酶链式反应、测序、显微镜鉴定或动物接种分离，或两者兼而有之地被诊断。发现48人(30名妇女或女孩，中位年龄45岁，范围为7个月至75岁)。其中32人为确诊病例，16人为疑似病例。48例中无一例输血或脾切除。在地理上，病例分散分布在医院集水区。在32例确诊病例中，21例(66%)表现为发热，13例(41%)表现为头痛，12例(38%)表现为肌肉痛或关节痛，3例(9%)表现为寒战。14例(44%)患者有乏力，8例(25%)患者有头晕，8例(25%)患者有多眠。6名患者(19%)在扁虱叮咬部位周围有红斑性非瘙痒皮疹，2名患者(6%)有淋巴结病。7名(22%)和4名(13%)患者分别有贫血和血小板减少，14名确诊感染的患者中有7名(50%)肝脏转氨酶浓度升高。在确诊病例中，细胞间黏附分子3浓度(p
Background Human babesiosis is an emerging zoonosis. "Babesia venatoram" has been identified in only four asplenic men and a child so far. We aimed to describe the epidemiological, clinical, and laboratory characteristics of a series of cases with "B venatorum" infection identified in a sentinel hospital in China.Methods We recruited participants with a recent tick bite at Mudanjiang Forestry Central Hospital, Heilongjiang province, China. Cases were diagnosed through PCR followed by sequencing, microscopic identification, or isolation by animal inoculation, or both.Findings 48 individuals (30 women or girls; median age 45 years, range 7 months to 75 years) with "B venatorum" infection were identified. 32 of these individuals were confirmed cases and 16 were probable cases. None of the 48 cases had received a blood transfusion or had a splenectomy. Geographically, cases were distributed diffusely throughout the hospital catchment area. Of the 32 confirmed cases, 21 (66%) presented with a fever, 13 (41%) with a headache, 12 (38%) with myalgia or arthralgia, and three (9%) with chills. 14 (44%) patients had fatigue, eight (25%) had dizziness, and eight (25%) had hypersomnia. Six (19%) patients had an erythematous non-pruritic rash around the tick-bite site and two (6%) had lymphadenopathy. Seven (22%) and four (13%) patients had anaemia and thrombocytopenia, respectively, and seven (50%) of 14 patients with confirmed infection had increased hepatic transaminase concentrations. In the confirmed cases, concentrations of intercellular adhesion molecule 3 (p