Preliminary study of whole-brain CT perfusion imaging in patients with intracranial tumours adjacent to large blood vessels
Preliminary study of whole-brain CT perfusion imaging in patients with intracranial tumours adjacent to large blood vessels
复制标题
邻近大血管的颅内肿瘤患者全脑CT灌注成像初步研究
DOI：
10.1016/j.crad.2013.08.010
复制
发表时间：
2014-01-01
影响因子：
2.6
通讯作者：
Jiang, Y.
中科院分区：
文献类型：
--
作者：
Chen, T.;Guo, D.;Jiang, Y.
目的：探讨全脑CT灌注成像（WBCTP）在颅内大血管旁肿瘤中的应用价值。材料与方法：对35例临床和病理诊断为颅内大血管旁肿瘤的患者进行320排CT灌注成像。同时获得脑血流量（CBF）、脑血容量（CBV）、平均通过时间（MTT）、达峰时间（TTP）的三维CT灌注（3D-CTP）参数图和动态CT血管造影（4D-CTA）图像。采用后处理技术重建三维CT血管造影（3D-CTA）图像，包括容积再现（VR）、最小密度投影（MIP）以及肿瘤与CTA的融合图像。结果：WBCTP图像无伪影，图像质量良好。在3D-CTP图上识别出异常灌注区域。脑膜瘤组18例，脑胶质瘤组16例，脑血流量和脑血容量差异有统计学意义（P < 0.05）。30例CTA可观察到肿瘤的供血静脉和引流静脉。肿瘤压迫周围大动脉18例，肿瘤包裹周围大动脉6例。10例显示静脉窦受压和轻度变形，4例显示上级矢状窦受侵，血管腔部分闭塞.结论：WBCTP技术可对颅内大血管旁肿瘤进行综合评价.该技术对颅内肿瘤的诊断和评价颅内肿瘤与周围大血管的关系具有重要价值。(C)2013年皇家放射科医师学院。由爱思唯尔有限公司出版。保留所有权利。
AIM: To explore the value of whole-brain computed tomography perfusion (WBCTP) imaging in patients with intracranial tumours adjacent to large blood vessels.MATERIALS AND METHODS: WBCTP with 320-row CT was performed in 35 patients with clinically and pathologically diagnosed intracranial tumours adjacent to large blood vessels. Three-dimensional CT perfusion (3D-CTP) parameter maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and dynamic CT angiography (4D-CTA) images were obtained simultaneously. Three-dimensional CT angiography (3D-CTA) images, including volume rendering (VR), minimum intensity projection (MIP), and fusion images of the tumour with CTA, were reconstructed using post-processing techniques. The image quality, CTP and CTA characteristics were analysed.RESULTS: All WBCTP images could be evaluated without artefacts. Abnormal perfusion areas were identified on 3D-CTP maps. Significant differences in CBF and CBV were detected between meningioma (n = 18) and glioma (n = 16; p < 0.05). The blood supplying and draining veins of the tumour could be observed on CTA in 30 cases. The surrounding large arteries were compressed and dislocated by tumours in 18 cases and were wrapped up in six cases. Compression and mild deformation of the venous sinuses were visualized in 10 cases, and in four cases, the superior sagittal sinus was invaded and the vessel lumen was partially blocked.CONCLUSION: Comprehensive evaluation of intracranial tumours adjacent to large blood vessels could be achieved with the WBCTP technique. This technique has great value for the diagnosis of intracranial tumours and for evaluation of the relationship of intracranial tumours to surrounding large blood vessels. (C) 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.