Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia
Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia
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DOI：
10.1016/j.neulet.2007.01.005
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发表时间：
2007-03-26
影响因子：
2.5
通讯作者：
Gyo, Kiyofumi
中科院分区：
文献类型：
--
作者：
Fujita, Kensuke;Hakuba, Nobuhiro;Gyo, Kiyofumi
本文研究了蒙古沙土鼠耳蜗短暂缺血对螺旋神经节细胞（SGCs）的影响。缺血性损伤是通过阻断沙土鼠的双侧椎动脉15分钟。缺血后7天，SGCs的百分比下降到67.5%，从缺血前的基线在基础的转折。免疫组化染色显示TUNEL阳性反应的SGCs与破碎的核。此外，我们还研究了GRB1（gRB1）对SGCs缺血损伤的保护作用。缺血后7天，gRb 1治疗组的听性脑干反应阈值偏移显著降低，SGCs的百分比从缺血前基线的基础旋转下降至90.2%。这些结果表明，Rb 1预防蒙古沙土鼠SGCs缺血损伤引起的听力损失。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
The effects of transient cochlear ischemia on spiral ganglion cells (SGCs) were studied in Mongolian gerbils. Ischemic insult was induced by occluding the bilateral vertebral arteries of gerbils for 15 min. Seven days after ischemia, the percentage of SGCs decreased to 67.5% from the preischemic baseline in the basal turn. Evaluation with immunohistochemical staining showed TUNEL-positive reactions in the SGCs with fragmented nuclei. In addition, we investigated the protective effects of ginsenoside Rb1 (gRb1) against ischemic injury to SGCs. Seven days after ischemia, the auditory brainstem response threshold shift was significantly reduced and the percentage of SGCs decreased to 90.2% from the preischemic baseline in the basal turn in the gRb1-treated group. These findings suggest that Rb1 prevented hearing loss caused by ischemic injury to SGCs in Mongolian gerbils. (c) 2007 Elsevier Ireland Ltd. All rights reserved.