Boron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model.
Boron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model.
复制标题
硼中子捕获疗法用于治疗仓鼠颊囊模型中的口腔癌。
作者：
E. Kreimann;M. Itoiz;J. Longhino;H. Blaumann;O. Calzetta;A. Schwint
我们提出并验证了用于硼中子俘获治疗（BNCT）研究的口腔癌仓鼠颊袋模型，结果表明，硼苯丙氨酸向肿瘤组织输送36.9 +/- 17.5 ppm的硼，肿瘤：正常组织和肿瘤：血液的比例分别为2.4:1和3.2:1。在这里，我们报告了BNCT在实验模型中治疗口腔癌有用性的第一个证据。我们利用巴里洛切原子中心的RA-6反应堆的热化超热光束，评估了仓鼠颊袋肿瘤、癌前组织和正常口腔组织对硼苯丙氨酸介导的BNCT的反应。在治疗后15天内，78%的肿瘤完全缓解，另外13%的肿瘤部分缓解，几乎没有对正常组织造成损害。
We have proposed and validated the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies and shown that boronophenylalanine delivers potentially therapeutic 36.9 +/- 17.5 ppm boron to tumor tissue with tumor:normal tissue and tumor:blood ratios of 2.4:1 and 3.2:1, respectively. Here we report the first evidence of the usefulness of BNCT for the treatment of oral cancer in an experimental model. We assessed the response of hamster cheek pouch tumors, precancerous tissue, and normal oral tissue to boronophenylalanine-mediated BNCT using the thermalized epithermal beam of the RA-6 Reactor at the Bariloche Atomic Center. BNCT leads to complete remission by 15 days posttreatment in 78% of tumors and partial remission in an additional 13% of tumors with virtually no damage to normal tissue.
通过黑色素前体类似物对硼苯丙氨酸选择性地将硼递送至黑色素瘤以外的肿瘤。
影响因子：
11.2
作者：
Coderre,JA;Glass,JD;Fairchild,RG;Micca,PL;Fand,I;Joel,DD
通讯作者：
Joel,DD
用对硼苯丙氨酸硼中子俘获疗法治疗小鼠黑色素瘤：使用发病指数进行剂量反应分析。
影响因子：
3.4
作者：
Coderre,JA;Slatkin,DN;Micca,PL;Ciallella,JR
通讯作者：
Ciallella,JR