Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer.
Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer.
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根治性子宫切除术联合辅助放疗与根治性放疗治疗FIGO IIB期宫颈癌的比较
DOI：
10.1186/1471-2407-14-63
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发表时间：
2014-02-04
期刊：
影响因子：
3.8
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Chai Y;Wang T;Wang J;Yang Y;Gao Y;Gao J;Gao S;Wang Y;Zhou X;Liu Z
本研究的目的是比较妇产科联合会(FIGO)IIB期宫颈癌根治术后辅助性放疗与根治性放射治疗的疗效。148例患者接受了根治性子宫切除术、盆腔淋巴结清扫术和辅助放射治疗(手术组)。这些患者与290名仅接受根治性放射治疗的患者(基于RT的组)进行了比较。结果两组的复发率(16.89%vs.12.41%，p = 0.200)、复发率(对数等级，p = 0.211)、复发率(对数等级，p = 0.347)、局部控制率(对数等级，p = 0.668)相似。此外，手术组急性3-4级胃肠道反应和晚期3-4级下肢淋巴水肿的发生率显著高于基于RT的组。COX多因素分析显示，两组患者的生存结局无显著差异，肿瘤直径和组织病理改变是影响预后的重要因素。结论FIGOⅡB期宫颈癌根治性放疗与根治性子宫切除术后放疗相比，根治性放射治疗相关并发症少，预后相似。
BackgroundThe goal of this study was to compare treatment outcomes for Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical carcinoma patients receiving radical surgery followed by adjuvant postoperative radiotherapy versus radical radiotherapy.MethodsMedical records of FIGO stage IIB cervical cancer patients treated between July 2008 and December 2011 were retrospectively reviewed. A total of 148 patients underwent radical hysterectomy with pelvic lymph node dissection followed by adjuvant radiotherapy (surgery-based group). These patients were compared with 290 patients that received radical radiotherapy alone (RT-based group). Recurrence rates, progression-free survival (PFS), overall survival (OS), local control rates, and treatment-related complications were compared for these two groups.ResultsSimilar rates of recurrence (16.89% vs. 12.41%, p = 0.200), PFS (log-rank, p = 0.211), OS (log-rank, p = 0.347), and local control rates (log-rank, p = 0.668) were observed for the surgery-based group and the RT-based group, respectively. Moreover, the incidence of acute grade 3–4 gastrointestinal reactions and late grade 3–4 lower limb lymphedema were significantly higher for the surgery-based group versus the RT-based group. Cox multivariate analyses found no significant difference in survival outcome between the two groups, and tumor diameter and histopathology were identified as significant prognostic factors for OS.ConclusionsRadical radiotherapy was associated with fewer treatment-related complications and achieved comparable survival outcomes for patients with FIGO stage IIB cervical cancer compared to radical hysterectomy followed by postoperative radiotherapy.
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影响因子：
4.7
作者：
Folkert, Michael R.;Shih, Karin K.;Alektiar, Kaled M.
通讯作者：
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影响因子：
3.3
作者：
Park, Tchan-Kyu;Kwon, Ja-Young;Kim, Gwi Eon
通讯作者：
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影响因子：
168.9
作者：
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作者：
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通讯作者：
Kimura, Tadashi
DOI：
10.1016/j.ijrobp.2012.01.064
发表时间：
2012-11-15
影响因子：
7
作者：
Gondi, Vinai;Bentzen, Soren M.;Sklenar, Kathryn L.;Dunn, Emily F.;Petereit, Daniel G.;Tannehill, Scott P.;Straub, Margaret;Bradley, Kristin A.
通讯作者：
Bradley, Kristin A.