An Event-Related Potential Study of Response Inhibition in ADHD With and Without Prenatal Alcohol Exposure
An Event-Related Potential Study of Response Inhibition in ADHD With and Without Prenatal Alcohol Exposure
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DOI：
10.1111/j.1530-0277.2009.01130.x
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发表时间：
2010-04-01
影响因子：
3.2
通讯作者：
Jacobson, Sandra W.
中科院分区：
文献类型：
--
作者：
Burden, Matthew J.;Jacobson, Joseph L.;Jacobson, Sandra W.
背景：有产前酒精暴露史的个体出现的注意力和认知问题通常与注意缺陷多动障碍(ADHD)相关，但很少有研究直接评估它们对神经行为结果的独特影响。方法：我们记录了有产前酒精暴露和儿童ADHD病史的年轻人在Go/No-Go反应抑制任务中的事件相关电位(ERPs)。结果：无论产前酒精暴露如何，儿童ADHD患者抑制反应的准确性都较低。然而，只有没有产前酒精暴露的ADHD组在No-Go和Go之间的P3差异显著减小，这可能反映了一种与神经加工水平的抑制控制有关的更努力的策略。结论：这一发现支持了越来越多的证据表明，特发性ADHD症状的表现可能源于一种不同于产前酒精暴露相关的ADHD症状的神经生理过程。产前接触酒精并出现ADHD症状的人可能代表了一种独特的ADHD内表型，这可能需要与那些被发现有效治疗特发性ADHD的人不同的治疗方法。
Background:The attention and cognitive problems seen in individuals with a history of prenatal alcohol exposure often resemble those associated with attention deficit hyperactivity disorder (ADHD), but few studies have directly assessed the unique influence of each on neurobehavioral outcomes.Methods:We recorded event-related potentials (ERPs) during a Go/No-go response inhibition task in young adults with prospectively obtained histories of prenatal alcohol exposure and childhood ADHD.Results:Regardless of prenatal alcohol exposure, participants with childhood ADHD were less accurate at inhibiting responses. However, only the ADHD group without prenatal alcohol exposure showed a markedly diminished P3 difference between No-go and Go, which may reflect a more effortful strategy related to inhibitory control at the neural processing level.Conclusion:This finding supports a growing body of evidence suggesting that the manifestation of idiopathic ADHD symptoms may stem from a neurophysiologic process that is different from the ADHD symptomatology associated with prenatal alcohol exposure. Individuals who have been prenatally exposed to alcohol and present with ADHD symptomatology may represent a unique endophenotype of the disorder, which may require different treatment approaches from those found to be effective with idiopathic ADHD.