Melatonin protects against the effects of chronic stress on sexual behaviour in male rats
Melatonin protects against the effects of chronic stress on sexual behaviour in male rats
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DOI：
10.1097/00001756-200111160-00018
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发表时间：
2001-11-16
期刊：
影响因子：
1.7
通讯作者：
LaMarre, AK
中科院分区：
文献类型：
--
作者：
Brotto, LA;Gorzalka, BB;LaMarre, AK
本文探讨了慢性温和应激(CMS)对雄性大鼠性行为和湿狗抖动(WDS)的影响。WDS是一种5-HT2A型受体介导的行为。此外，还观察了5-HT2A型受体拮抗剂褪黑素对这些影响的缓解作用。CMS程序导致WDS显著增加，性行为各方面总体减少。同时给予褪黑素可减弱CMS对性行为的影响，但不能减弱5-HT2a激动剂1-(2，5-dimethoxy-4-iodophenyl)-2-aminopropane，对自发性WDS或WDS的影响，提示其作用机制不同于单独的5-HT2a拮抗剂。这些结果首次证明，褪黑素显著地保护人们免受慢性应激源对性行为的有害影响。(C)2001年，Lippincott Williams&Wilkins。
The effects of chronic mild stress (CMS) on both sexual behaviour and wet dog shakes (WDS), a serotonergic type 2A (5-HT2A) receptor-mediated behaviour, were explored in the male rat In addition, the possible attenuation of these effects by chronic treatment with melatonin, a putative 5-HT2A antagonist, was examined. The CMS procedure resulted in a significant increase in WDS and an overall decrease in all aspects of sexual behaviour. Concurrent melatonin administration attenuated the CMS-induced effects on sexual behaviour, but not the effects on either spontaneous WDS or WDS in response to the 5-HT2A agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, suggesting a mechanism of action other than exclusive 5-HT2A antagonism. These results are the first to demonstrate that melatonin significantly protects against the detrimental effects of a chronic stressor on sexual behaviour. (C) 2001 Lippincott Williams & Wilkins.