Monitoring ion-channel function in real time through quantum decoherence
Monitoring ion-channel function in real time through quantum decoherence
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DOI：
10.1073/pnas.1002562107
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发表时间：
2010-11-02
影响因子：
11.1
通讯作者：
Hollenberg, Lloyd C. L.
中科院分区：
文献类型：
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作者：
Hall, Liam T.;Hill, Charles D.;Hollenberg, Lloyd C. L.
在药物发现中，对于具有宽场能力的细胞膜离子通道操作的检测存在明确且迫切的需求。现有技术通常是侵入性的或需要专门的纳米结构。我们表明量子纳米技术可以提供一个解决方案。纳米金刚石中的氮空位（NV）中心作为纳米尺度过程的单原子量子探针引起了极大的兴趣。然而，到目前为止，人们对NV探针在复杂生物环境中的量子行为一无所知。我们探讨了量子动力学的NV探针接近离子通道，脂质双层，和周围的水环境。我们的理论结果表明，实时检测离子通道操作在毫秒级的分辨率是可能的，通过直接监测的量子退相干的NV探针。由于有可能扫描和扩展到基于阵列的系统，这一结论可能对纳米生物学和药物发现产生广泛的影响。
In drug discovery, there is a clear and urgent need for detection of cell-membrane ion-channel operation with wide-field capability. Existing techniques are generally invasive or require specialized nanostructures. We show that quantum nanotechnology could provide a solution. The nitrogen-vacancy (NV) center in nanodiamond is of great interest as a single-atom quantum probe for nanoscale processes. However, until now nothing was known about the quantum behavior of a NV probe in a complex biological environment. We explore the quantum dynamics of a NV probe in proximity to the ion channel, lipid bilayer, and surrounding aqueous environment. Our theoretical results indicate that real-time detection of ion-channel operation at millisecond resolution is possible by directly monitoring the quantum decoherence of the NV probe. With the potential to scan and scale up to an array-based system, this conclusion may have wide-ranging implications for nanoscale biology and drug discovery.