Synthesis and biological evaluation of polyhydroxycurcuminoids
Synthesis and biological evaluation of polyhydroxycurcuminoids
复制标题
DOI：
10.1016/j.bmc.2005.06.050
复制
发表时间：
2005-12-01
影响因子：
3.5
通讯作者：
Subbaraju, GV
中科院分区：
文献类型：
--
作者：
Venkateswarlu, S;Ramachandra, MS;Subbaraju, GV
以适当保护的羟基苯甲醛和乙酰丙酮为原料，经缩合、脱保护，合成了一系列姜黄素类似物（1-3，5a-5 t）。采用超氧阴离子自由基四氮唑蓝法和DPPH自由基清除法测定了这些化合物的抗氧化活性，结果表明多羟基姜黄素类化合物（5l-5s）具有较好的抗氧化活性。这些类似物显示出对淋巴细胞的细胞毒性和对道尔顿淋巴瘤腹水肿瘤细胞的有希望的减瘤活性。(c)2005爱思唯尔有限公司保留所有权利。
A series of curcurnin analogs (1-3, 5a-5t) was synthesized through the condensation of appropriately protected hydroxy-benzaldehydes with acetylacetone, followed by deprotection. The antioxidant activity of these analogs was determined by superoxide free radical nitroblue tetrazolium and DPPH free radical scavenging methods and the polyhydroxycurcuminoids (5l-5s) displayed excellent antioxidant activity. These analogs showed cytotoxicity to lymphocytes and promising tumor-reducing activity on Dalton's lymphoma ascites tumor cells. (c) 2005 Elsevier Ltd. All rights reserved.