Atypical activation of action-semantic network in adolescents with autism spectrum disorder
Atypical activation of action-semantic network in adolescents with autism spectrum disorder
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DOI：
10.1016/j.bandc.2017.06.004
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发表时间：
2017-10-01
影响因子：
2.5
通讯作者：
Foundas, Anne L.
中科院分区：
文献类型：
--
作者：
Knaus, Tracey A.;Burns, Claire;Foundas, Anne L.
在典型的成年人中，功能磁共振成像研究表明，在动作词处理过程中，主要和前运动区域被激活。自闭症谱系障碍（ASD）是一种以社交和沟通障碍为特征的神经发育障碍。ASD研究显示了非典型的语义处理和运动缺陷。本研究旨在探讨自闭症儿童对动词的语义加工。15名ASD青少年和19名发育正常的青少年，11-16岁，完成了语义相似性判断任务的功能磁共振成像。在任务准确性和反应时间方面没有差异。在组水平上，两组都激活了左侧语言区;对照组（但不是ASD）也激活了左侧前辅助运动区（pre-SMA）。在ASD患者中，左额叶激活减少和这些区域内激活的左侧化减少与更短的反应时间和更好的语言技能相关。更多的左颞叶激活与ASD患者更好的语言能力相关。SMA前激活的差异可能与运动计划缺陷或ASD中语义任务方法的差异有关。结果表明，左额叶语言区可能是效率较低的ASD和那些谁可以弥补招募更多的右半球同源可能会导致更好的语言能力。
In typical adults, fMRI studies have shown activation of primary and pre-motor regions during action word processing. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments. ASD studies have shown atypical semantic processing and motor deficits. The objective of this study was to examine semantic processing of verbs in ASD. 15 ASD adolescents and 19 typically developing adolescents, 11-16 years, completed a semantic similarity judgment task during fMRI. There were no differences in task accuracy or reaction time. At the group level, both groups had activation in left language areas; controls, but not ASD, also had activation in the left pre-supplementary motor area (pre-SMA). In ASD, less left frontal activation and reduced left lateralization of activation within these regions was associated with shorter reaction times and better language skills. More left temporal activation was associated with better language abilities in ASD. Differences in pre-SMA activation may relate to motor planning deficits or differences in approach to the semantic task in ASD. Results suggest that left frontal language areas may be less efficient in ASD and those who can compensate by recruiting more right hemisphere homologues may result in better language abilities.