Relationship between urinary bisphenol a levels and cardiovascular diseases in the US adult population, 2003-2014
Relationship between urinary bisphenol a levels and cardiovascular diseases in the US adult population, 2003-2014
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2003 年至 2014 年美国成年人尿双酚 A 水平与心血管疾病的关系
DOI：
10.1016/j.ecoenv.2020.110300
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发表时间：
2020-04-01
影响因子：
6.8
通讯作者：
Li, Yingjun
中科院分区：
文献类型：
--
作者：
Cai, Shaofang;Rao, Xianming;Li, Yingjun
越来越多的证据表明，心血管系统是双酚a （BPA）的潜在靶点。尽管一些研究揭示了BPA与几种心血管疾病（CVD）结局和CVD风险因素之间的关系，但尚未发表的研究调查了尿液BPA与中风风险之间的联系。方法：数据来源于2003 - 2014年美国国家健康与营养调查（NHANES），选取年龄为bb0 = 20岁的代表性样本（n = 9139）。我们采用多变量logistic回归模型来估计四分位数和自然对数转换后的尿液BPA浓度与五种特定CVD结局和总CVD之间的关系。结果：在四分位数分析中，与最低四分位数相比，尿液BPA水平最高与心肌梗死（MI） （OR = 1.73, 95% CI = 1.11-2.69）和中风（OR = 1.61, 95% CI = 1.09-2.36）患病率增加相关。in -转化双酚a浓度每单位（mu g/g肌酐）的增加分别与19%、19%、25%、29%、20%和16%的充血性心力衰竭、冠心病、心绞痛、心肌梗死、中风和总心血管疾病的比值比增加显著相关。在男性中发现了类似的关联，而不是女性。结论：我们提供了美国人群尿中BPA浓度与中风呈正相关的首要证据。尿中BPA水平也与充血性心力衰竭、冠心病、心绞痛、心肌梗死以及总心血管疾病呈正相关。这些关联在男性中更为明显。有必要进行协调良好的前瞻性研究，以获得BPA对心血管疾病的人体影响。
Background Emerging evidence has identified cardiovascular system as a potential target of Bisphenol A (BPA). Although a few studies have revealed the relationship between BPA and the risk of several cardiovascular diseases (CVD) outcomes and CVD risk factors, no published studies have investigated the link between urinary BPA and the risk of stroke.Methods: Data were derived from the United States National Health and Nutrition Examination Surveys (NHANES), with a representative sample aged >= 20 years (n = 9139) from 2003 to 2014. We performed multivariable logistic regression model to estimate associations between quartiles and natural logarithm transformed urinary BPA concentrations and five specific CVD outcomes and total CVD.Results: In quartile analysis, highest level of urinary BPA was associated with increased prevalence of myocardial infarction (MI) (OR = 1.73, 95% CI = 1.11-2.69) and stroke (OR = 1.61, 95% CI = 1.09-2.36), when compared with those at the lowest quartile. Per unit (mu g/g creatinine) increment in In-transformed BPA concentration was shown to be significantly associated with 19%, 19%, 25%, 29%, 20%, and 16% increased odds ratios of prevalence of congestive heart failure, coronary heart disease (CHD), angina pectoris, MI, stroke and total CVD among total participants, respectively. Similar associations were found in males rather than in females.Conclusion: We provided the premier evidence of positive relationship between urinary BPA concentration and stroke in U.S. population. Urinary BPA levels were also positively correlated with congestive heart failure, CHD, angina pectoris, MI, as well as total CVD. These associations were more evident in males. Well-coordinated and prospective studies are warranted to gain the human effects of BPA on CVD.