Effects of aldosterone on potassium distribution.
Effects of aldosterone on potassium distribution.
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醛固酮对钾分布的影响。
DOI：
10.1152/ajpregu.1982.243.5.r526
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Jackson,TE
中科院分区：
文献类型：
--
作者：
Young,DB;Jackson,TE
为了评估醛固酮的长期变化对体内钾分布的影响，进行了两组实验。在第一组中，7只正常的狗以高生理速率（250微克/天）连续输注醛固酮。分别于输注前、输注后第4、6天测定血清总交换性钾（Ke）和血浆钾浓度（KP）。输注6天后，KP下降了20%，而Ke下降了8%;醛固酮输注改变了细胞外钾和全身钾的比例。在第二项研究中，10只肾上腺切除的狗首先接受50微克/天的醛固酮输注，然后接受250微克/天的醛固酮输注。在每一个醛固酮输注水平上，通过静脉输注给予三个水平的钾摄入。当动物在每个醛固酮和钾水平下处于电解质平衡时（每个输注水平至少7天后），测量Ke（表示为meq/kg）和KP。这两个变量相互作图，Ke为自变量。犬接受50微克/天醛固酮时采集的数据用方程KP = 0.100Ke + 0.055描述，而接受250微克/天醛固酮时采集的数据用方程KP = 0.057Ke + 1.30拟合。两者的相关系数分别为0.778和0.760。在P <0.02的水平上，回归分析有显著差异。来自两组实验的数据与醛固酮改变钾在细胞内和细胞外空间之间的分布的假设是一致的，在较高水平的醛固酮下，总钾的更大部分在细胞内。
To assess the effects of long-term changes in aldosterone on potassium distribution within the body, two groups of experiments were conducted. In the first, seven normal dogs received continuous infusion of aldosterone at a high physiological rate, 250 micrograms/day. Total exchangeable potassium (Ke) and plasma potassium concentration (KP) were measured before and 4 and 6 days after aldosterone infusion. KP fell by 20% while Ke decreased by 8% after 6 days of infusion; the ratio between extracellular and total body potassium had been altered by the aldosterone infusion. In the second study, 10 adrenalectomized dogs received aldosterone infusion first at 50 micrograms/day, then at 250 micrograms/day. While on each level of aldosterone infusion, three levels of potassium intake were given by iv infusion. When the animals were in electrolyte balance at each level of aldosterone and potassium (after at least 7 days on each level of infusion), Ke (expressed as meq/kg) and KP were measured. The two variables were plotted against each other, Ke being the independent variable. Data taken while the dogs received 50 micrograms/day aldosterone were described by the equation, KP = 0.100Ke + 0.055, while those obtained at 250 micrograms/day were fitted by the equation, KP = 0.057Ke + 1.30. The correlation coefficients for the two were 0.778 and 0.760, respectively. The regressions were significantly different at a level of P less than 0.02. Data from the two groups of experiments are consistent with the hypothesis that aldosterone alters the distribution of potassium between the intra- and extracellular spaces, a greater portion of total potassium being intracellular at higher levels of aldosterone.