LnCompare: gene set feature analysis for human long non-coding RNAs
LnCompare: gene set feature analysis for human long non-coding RNAs
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LnCompare：人类长非编码RNA的基因集特征分析
DOI：
10.1093/nar/gkz410
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发表时间：
2019-07-02
影响因子：
14.9
通讯作者：
Li, Jianwei
中科院分区：
文献类型：
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作者：
Carlevaro-Fita, Joana;Liu, Leibo;Li, Jianwei
对长链非编码rna （lncRNAs）生物学作用的兴趣导致越来越多的研究产生了大量的候选基因，例如，在两种情况下的差异表达。对于蛋白质编码基因集，本体和途径分析是从基因特征的统计富集中产生新见解的强大工具。在这里，我们介绍了LnCompare web服务器，这是一个用于研究lncRNA基因集特性的等效资源。基因集特征比较模式测试在一组定量和分类特征之间的富集，跨越基因结构，进化守恒，表达，亚细胞定位，重复序列和疾病关联。此外，在相似基因识别模式中，用户可以通过在定义的特征范围内的相似性来识别其他lncrna。除了整个功能资源外，还可以下载表格和图形格式的综合结果。LnCompare将使研究人员能够从lncRNA基因集中提取有用的假设和候选基因。
Abstract Interest in the biological roles of long noncoding RNAs (lncRNAs) has resulted in growing numbers of studies that produce large sets of candidate genes, for example, differentially expressed between two conditions. For sets of protein-coding genes, ontology and pathway analyses are powerful tools for generating new insights from statistical enrichment of gene features. Here we present the LnCompare web server, an equivalent resource for studying the properties of lncRNA gene sets. The Gene Set Feature Comparison mode tests for enrichment amongst a panel of quantitative and categorical features, spanning gene structure, evolutionary conservation, expression, subcellular localization, repetitive sequences and disease association. Moreover, in Similar Gene Identification mode, users may identify other lncRNAs by similarity across a defined range of features. Comprehensive results may be downloaded in tabular and graphical formats, in addition to the entire feature resource. LnCompare will empower researchers to extract useful hypotheses and candidates from lncRNA gene sets.