Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) for micronization of levofloxacin hydrochloride
Supercritical fluid assisted atomization introduced by hydrodynamic cavitation mixer (SAA-HCM) for micronization of levofloxacin hydrochloride
复制标题
水力空化混合器（SAA-HCM）引入超临界流体辅助雾化用于盐酸左氧氟沙星微粉化
DOI：
10.1016/j.supflu.2007.07.008
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发表时间：
2008-01-01
影响因子：
3.9
通讯作者：
Zhu, Zi-Qiang
中科院分区：
文献类型：
--
作者：
Cai, Mei-Qiang;Guan, Yi-Xin;Zhu, Zi-Qiang
在超临界流体辅助雾化(SAA)过程中引入了水力空化混合器(HCM)来改善传质。SAA-HCM导致了更均匀的初级液滴，因此，颗粒尺寸分布更窄。以盐酸左氧氟沙星为模型药物，考察了空化发生器对沉淀物的形态、大小和分布的影响。此外，还详细考察了CO2与液体的进料比、溶质浓度等工艺参数对反应的影响。在不同的CO2溶液进料比和溶质浓度下，得到了球形的无定形微米级颗粒。在所有情况下，都会产生直径小于2.1微米的颗粒。SAA-HCM有望成为制备适合肺部给药的微粒的一种很有前途的技术。(C)2007 Elsevier B.V.保留所有权利。
A hydrodynamic cavitation mixer (HCM) was introduced in the supercritical fluid assisted atomization (SAA) process to improve mass transfer. SAA-HCM resulted in a more homogenous primary droplet and, as a consequence, narrower particle size distributions. Levofloxacin hydrochloride (LH) being selected as a model drug, the effects of cavitation generator on morphology, size, and distribution of precipitated particles were evaluated. In addition, the influences of several process parameters, such as the feed ratio between CO2 and liquid solution, solute concentration, etc., were investigated in detail. Spherical amorphous micron-sized particles were obtained at different CO2-solution feed ratio and solute concentrations. In all cases, particles with diameters smaller than 2.1 mu m were produced. The SAA-HCM is expected to be a promising technique for producing microparticles suitable for pulmonary delivery in drug delivery applications. (C) 2007 Elsevier B.V. All rights reserved.