The onset of human parturition
The onset of human parturition
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DOI：
10.1007/s00404-010-1365-9
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发表时间：
2010-06-01
影响因子：
2.6
通讯作者：
Kamel, Remah Moustafa
中科院分区：
文献类型：
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作者：
Kamel, Remah Moustafa
尽管生殖科学和技术取得了令人印象深刻的进步，但人类分娩的机制仍然不清楚。由于人类的分娩与动物的分娩不同，因此本研究旨在收集目前可以解释人类分娩何时以及为何发生的理论。在布里斯托大学医学和牙科学院进行的一项全面回顾研究中，英国，MetaLib，大学基于网络的电子图书馆，通过不同的医学数据库交叉搜索人类分娩开始背后的因素，例如;联合和补充医学数据库（AMED），BIOSIS Previews on Web of Knowledge，PubMed，科克伦图书馆，Medline和Web of Science，除了相关的印刷医学杂志和期刊。研究表明，在人类分娩过程中涉及的潜在因素包括雌激素和孕激素水平的变化，前列腺素和催产素的产生增加以及促肾上腺皮质激素释放激素和皮质醇的高水平是参与人类分娩过程的一些潜在因素。炎症反应与细胞因子的释放是最被接受的理论之一，为长期和早产。很可能所有这些因素和其他尚未发现的因素之间的相互作用协调一致地启动了妇女的分娩过程，结果表明，分娩是一个复杂的、部分确定的事件的结果，受到内分泌、神经和免疫系统的各种机制和介质的严格调节。不幸的是，没有一个是完全阐明。
Despite impressive progress in the science and technology of reproduction, the mechanism by which labour is initiated in humans remains obscure.As the labour in humans is a distinct event differs from what happens in animals, this study aims to gather the current theories that could explain when and why the onset of human parturition occurs.In a comprehensive review study done at the School of Medicine and Dentistry, University of Bristol, United Kingdom, MetaLib, the university web-based electronic library, was cross-searched for the factors behind the onset of labour in humans through different medical databases such as; Allied and Complementary Medicine Database (AMED), BIOSIS Previews on Web of Knowledge, PubMed, Cochrane Library, Medline and Web of Science, in-addition to the relevant printed medical journals and periodicals.The study revealed that among the potential factors involved in the process of human parturition are the changes in hormonal levels of estrogen and progesterone, increased production of prostaglandins and oxytocin, and the high levels of corticotrophin releasing hormone and cortisol are some among the potential factors involved in the process of human parturition. Inflammatory reactions with the release of cytokines are among the most accepted theories for term and preterm labours. It is most likely that the interaction between all these factors and others, yet to be discovered, play in harmony to initiate the process of labour in women.The result show that birth is a result of complex, partially defined, events that are tightly regulated by a variety of mechanisms and mediators of endocrine, nervous and immune systems. Unfortunately, none of them is completely elucidated.