Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
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DOI：
10.1086/498122
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发表时间：
2005-12-01
影响因子：
9.8
通讯作者：
Okazaki, Y
中科院分区：
文献类型：
--
作者：
Arinami, T;Arinami, T;Okazaki, Y
日本精神分裂症同胞对连锁组（JSSLG）是一个多地点合作研究小组，旨在为日本精神分裂症的受影响同胞对（ASP）研究创建国家资源。我们使用了高密度单核苷酸多态性（SNP）基因分型试验，Illumina BeadArray连锁图谱面板（第4版），包括5,861个SNP，进行JSSLG样本的全基因组连锁分析，包括236个日本家庭，268个非独立的ASP精神分裂症。所有受试者均为日本人。在这些家庭中，122个家庭包括相同的主题分析与短串联重复标记。所有先证者和他们的兄弟姐妹，除了7个兄弟姐妹患有情感障碍外，都患有精神分裂症。在排除具有高连锁不平衡的SNP后，我们发现精神分裂症与染色体1p21.2-1p13.2（LOD = 3.39）连锁的显著证据，以及与14q11.2（LOD = 2.87）、14q11.2- q13.2（LOD = 2.33）和20p12.1-p11.2（LOD = 2.33）连锁的暗示证据。尽管与这些区域的联系很少受到关注，但这些区域包括在刘易斯等人报告的10个区域中或部分重叠，这些区域通过了荟萃分析的两个综合标准。本研究的结果，据我们所知，这是第一个全基因组分析精神分裂症的ASP的一个单一的亚洲种族，是可比的ASP的欧洲血统的分析表明存在精神分裂症的易感基因座是常见的不同种族群体，但可能有不同的种族特异性的影响。
The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2- q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little x attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.