Ratiometric photoluminescence sensing based on Ti3C2 MXene quantum dots as an intracellular pH sensor
Ratiometric photoluminescence sensing based on Ti3C2 MXene quantum dots as an intracellular pH sensor
复制标题
基于 Ti3C2 MXene 量子点的比率光致发光传感作为细胞内 pH 传感器
DOI：
10.1039/c7nr06958h
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发表时间：
2018-01-21
期刊：
影响因子：
6.7
通讯作者：
Song, Hongwei
中科院分区：
文献类型：
--
作者：
Chen, Xu;Sun, Xueke;Song, Hongwei
细胞内pH感知非常重要，可以作为监测各种疾病的演变和细胞健康的指标。在这里，我们通过超声切割和水热方法开发了一类新的表面功能化的MXene量子点，Ti3C2，并进一步探索了它们对细胞内pH的传感。功能化的Ti3C2量子点由于尺寸效应和表面缺陷而显示出明亮的激发相关蓝色光致发光(PL)。同时，Ti3C2量子点由于表面缺陷的去质子化而表现出较高的荧光响应。此外，将高pH敏感的Ti3C2量子点与pH不敏感的[Ru(DPP)(3)]Cl2结合起来，我们研制了一种比率计量式pH传感器来定量监测细胞内的pH值。这些新颖的MXene量子点可以作为开发实用的荧光纳米传感器的一个有前途的平台。
Intracellular pH sensing is of importance and can be used as an indicator for monitoring the evolution of various diseases and the health of cells. Here, we developed a new class of surface-functionalized MXene quantum dots (QDs), Ti3C2, by the sonication cutting and hydrothermal approach and further explored their intracellular pH sensing. The functionalized Ti3C2 QDs exhibit bright excitation-dependent blue photoluminescence (PL) originating from the size effect and surface defects. Meanwhile, Ti3C2 QDs demonstrate a high PL response induced by the deprotonation of the surface defects. Furthermore, combining the highly pH sensitive Ti3C2 QDs with the pH insensitive [Ru(dpp)(3)] Cl-2, we developed a ratiometric pH sensor to quantitatively monitor the intracellular pH values. These novel MXene quantum dots can serve as a promising platform for developing practical fluorescent nanosensors.