ABSENCE OF ANTIBODIES TO AIDS VIRUS IN HAEMOPHILIACS TREATED WITH HEAT-TREATED FACTOR VIII CONCENTRATE
ABSENCE OF ANTIBODIES TO AIDS VIRUS IN HAEMOPHILIACS TREATED WITH HEAT-TREATED FACTOR VIII CONCENTRATE
复制标题
用热处理因子 VIII 浓缩物治疗的血友病患者不存在艾滋病病毒抗体
DOI：
10.1016/s0140-6736(85)91043-8
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
P. Mannucci
中科院分区：
文献类型：
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作者：
Christine Rouzioux;S. Chamaret;Luc Montagnier;V. Carnelli;G. Rolland;P. Mannucci
作者（来自意大利米兰和法国巴黎）治疗了18名甲型血友病患者（之前未接受过治疗），并与29名对照患者（也是未接受过治疗的血友病患者）进行比较，研究淋巴结病相关病毒（LAV）的血清转化率，与试验组同期接受非加热商业浓缩物治疗的18例患者中，无抗-治疗前后LAV均为阳性，而对照组29例中有5例（17%）为阳性。没有病人出现爱滋病或相关疾病的病征。5例血清阳性对照患者除接受VIII因子浓缩物治疗外，无其他艾滋病危险因素。菲茨西蒙斯
The authors (from Milan, Italy, and Paris, France) treated 18 patients with haemophilia A (who had not been previously treated) with heat-treated factor VIII concentrate and investigated the rate of seroconversion to lymphadenopathy-associated virus (LAV) in comparison with 29 control patients, also untreated haemophiliacs, who were treated with non-heated commercial concentrates during the same period as the test group.None of the 18 patients in the test group were anti-LAV positive before or after treatment whereas 5 of the 29 control patients (17%) were. No patient has any symptom of AIDS or related diseases. The 5 seropositive control patients have no risk factor for AIDS other than treatment with factor VIII concentrate.newline˜D.W. FitzSimons