Research Advances on Structure and Function of the GARP Complex
Research Advances on Structure and Function of the GARP Complex
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GARP复合体结构与功能研究进展
DOI：
10.13417/j.gab.035.000664
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Lixin Li
中科院分区：
文献类型：
--
作者：
Zhe SHen;Hailong Zhang;Xiaonan Zhao;Xiaoli Yang;Lixin Li
在真核细胞中，物质交流是通过囊泡运输完成的。囊泡运输。包括囊泡萌芽、定向运输、束缚、对接和融合的过程。栓系过程是转运囊泡与靶细胞膜的初始接触过程。在这一过程中，有多种因素involved.in调控，如束缚因子、小GTP酶、SNARE等，其中GARP（golgi-associated retrograde.protein）复合物是内体-TGN逆行转运中的一种束缚因子.目前，人们对GARP的结构和功能有了一定的认识。本文就近年来GARP复合物的研究进展作一综述。
In eukaryotic cells, the material communication is accomplished by vesicle transport. Vesicle transport.includes the process of vesicle budding, directional transport, tethering, docking and fusion. Tethering process is.the initial contact between transport vesicles and target membrane. In this process, there are many factors involved.in regulation, such as tethering factors, small GTPases, SNAREs and so on. GARP (golgi-associated retrograde.protein) complex is a tethering factor in endosome-to-TGN retrograde transport. Currently, there is a certain understanding.about the structure and function of GARP. This review would summary the recent research progress of.GARP complex.