Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking
Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking
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DOI：
10.1016/j.celrep.2020.02.095
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发表时间：
2020-03-17
期刊：
影响因子：
8.8
通讯作者：
Britt, Jonathan P.
中科院分区：
文献类型：
--
作者：
Lafferty, Christopher K.;Yang, Angela K.;Britt, Jonathan P.
丘脑核（NAc）有助于行为抑制和强迫，但回路机制尚不清楚。最近的证据表明，杏仁核和丘脑的输入对行为施加相反的控制，就像直接和间接通路输出神经元一样。因此，这些NAc输入或细胞类型之间的对手过程可能是有效的奖励寻求的基础。我们评估的贡献，这些电路元件的鼠标操作性行为在反复出现的条件下，奖励是和不可用。虽然直接途径刺激是有益的和间接途径刺激厌恶，这两种细胞类型的活性升高期间的行为抑制，和抑制任一细胞类型选择性地增加非生产性的奖励寻求。杏仁核和丘脑的输入也是行为抑制所必需的，尽管它们都支持自我刺激并支配不同的NAc亚区。这些数据表明，有效的奖励寻求依赖于跨NAc细胞类型和输入的互补活动，而不是它们之间的对立过程。
The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when reward is and is not available. Although direct pathway stimulation is rewarding and indirect pathway stimulation aversive, the activity of both cell types is elevated during periods of behavioral suppression, and the inhibition of either cell-type selectively increases unproductive reward seeking. Amygdala and thalamic inputs are also necessary for behavioral suppression, even though they both support self-stimulation and innervate different NAc subregions. These data suggest that efficient reward seeking relies on complementary activity across NAc cell types and inputs rather than opponent processes between them.