Serum and urinary selenium levels in obese children: A cross-sectional study
Serum and urinary selenium levels in obese children: A cross-sectional study
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DOI：
10.1016/j.jtemb.2014.07.016
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发表时间：
2015-01-01
影响因子：
3.5
通讯作者：
Kocjan, Ryszard
中科院分区：
文献类型：
--
作者：
Blazewicz, Anna;Klatka, Maria;Kocjan, Ryszard
目的：为了解肥胖儿童血硒和尿硒水平，探讨硒对肥胖的影响，采用高分辨连续光源原子吸收光谱法（HR-CS-AAS）对80名6-17岁儿童（男40名，女40名）进行了硒含量测定。使用斯皮尔曼相关系数检验变量之间的相关性。采用U Mann-Whitney检验分析样品间硒含量的差异。测量的代谢危险因素（血压、血糖水平、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和总胆固醇）、年龄、性别和BMI相关。Logistic回归模型进行拟合，以确定肥胖与血清和尿硒含量相互作用的预测因素，分别。血清硒水平（p = 0.001，OR 0.74，95%CI 0.62-0.88）和总胆固醇水平（p = 0.001，OR 1.19，95%CI 1.08-1.31）是影响儿童肥胖的独立危险因素。观察到两种不同的尿硒模型：（i）硒水平（p < 0. 05）。0001，OR 0.70，95%CI 0.58-0.84）和血糖水平（p < 0.0001，OR 1.22，95%CI 1.10-1.35），和（ii）硒水平（p = 0.002，OR0.60，95%CI0.43 -0.83）和总胆固醇水平（p = 0.003，OR1.16，95%CI1.05 -1.28）。需要进行进一步的研究，以检查肥胖儿童是否是硒缺乏症的高危人群。(C)2014 Elsevier GmbH. All rights reserved.
Objective: To determine serum and urinary selenium (Se) levels in children with and without obesity, and to assess if Se influences the risk of obesity.Subjects and methods: High-resolution-continuum source-atomic absorption spectrometry (HR-CS-AAS) was used to determine the content of Se in 80 children (age 6-17; 40 boys, 40 girls). Correlations between variables were tested with the use of Spearman's correlation coefficient. U Mann-Whitney test was applied to assess the difference of Se contents in samples. Measured metabolic risk factors (blood pressure, glucose level, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol), age, gender, and BMI were correlated. Logistic regression models were fitted to identify predictors of obesity interacting with selenium content in serum and urine, separately.Results: Obese children, regardless of gender, had lower Se content. Se level in serum (p = 0.001, OR 0.74, 95%CI 0.62-0.88) and total cholesterol (p = 0.001, OR 1.19, 95%CI 1.08-1.31) were the independent factors significantly influencing the risk of obesity in children. Two separate models were observed for Se in urine: (i) Se level (p < 0. 0001, OR 0.70, 95%CI 0.58-0.84) and glucose level (p < 0.0001, OR 1.22, 95%CI 1.10-1.35), and (ii) Se level (p = 0.002, OR 0.60 95%CI 0.43-0.83) and total cholesterol level (p = 0.003, OR 1.16, 95%CI 1.05-1.28).Conclusion: The current study suggests a possible role of Se in obesity. Further research needs to be performed to check if obese children are an at-risk group for Se deficiency. (C) 2014 Elsevier GmbH. All rights reserved.