RENAL AND CARDIOVASCULAR EFFECTS OF CAFFEINE - A DOSE-RESPONSE STUDY
RENAL AND CARDIOVASCULAR EFFECTS OF CAFFEINE - A DOSE-RESPONSE STUDY
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DOI：
10.1042/cs0720749
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发表时间：
1987-06-01
期刊：
影响因子：
6
通讯作者：
JOHNSTON, GD
中科院分区：
文献类型：
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作者：
PASSMORE, AP;KONDOWE, GB;JOHNSTON, GD
1. 在八名健康男性志愿者中研究了增加口服咖啡因剂量（45、90、180 和 360 mg）对有效肾血浆流量（ERPF）、血浆肾素活性（PRA）、血清电解质、血浆去甲肾上腺素、血压和心率的影响。 2. 仅摄入 360 毫克咖啡因即可增加尿量。咖啡因剂量大于 90 毫克时，尿钠排泄显着增加。 ERPF 没有变化。 3. 360毫克咖啡因显着降低血清钾。 4.咖啡因以剂量相关的方式增加收缩压。舒张压也增加，但与剂量无关。 360 毫克剂量的咖啡因会导致心率后期增加。这些变化与 PRA 或血浆去甲肾上腺素的任何变化无关。
1. The effects of increasing oral doses of caffeine (45, 90, 180 and 360 mg) on effective renal plasma flow (ERPF), plasma renin activity (PRA), serum electrolytes, plasma noradrenaline, blood pressure and heart rate were studied in eight healthy male volunteers. 2. Urine volume was increased by 360 mg of caffeine only. At caffeine doses greater than 90 mg urinary sodium excretion was significantly increased. There were no changes in ERPF. 3. Serum potassium was significantly by 360 mg of caffeine. 4. Caffeine increased systolic pressure in a dose related manner. Diastolic pressure was also increased, but not in relation to dose. A 360 mg dose of caffeine produced a late increase in heart rate. These changes were not associated with any alterations in PRA or in plasma noradrenaline.