Hypothyroidism is common in Turner syndrome: Results of a five-year follow-up
Hypothyroidism is common in Turner syndrome: Results of a five-year follow-up
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DOI：
10.1210/jc.2004-1262
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发表时间：
2005-04-01
影响因子：
5.8
通讯作者：
Landin-Wilhelmsen, K
中科院分区：
文献类型：
--
作者：
El-Mansoury, M;Bryman, I;Landin-Wilhelmsen, K
特纳综合征（TS）是由性染色体畸变引起的。目的是研究成年TS患者甲状腺疾病的患病率和发病率。TS女性患者（n = 91;平均年龄37.7 ± 11岁）与年龄匹配的女性随机人群样本（n = 228）进行比较。基线时，15名（16%）TS妇女接受甲状腺功能减退治疗，另有8名（9%）血清TSH升高。结果，甲状腺功能减退症在TS患者中（25%）比对照组（2%; P < 0.0001）更常见。TS组血清游离T-4水平低于对照组（P = 0.02），血清TSH水平高于对照组（P < 0.0001）。在所有患有甲状腺功能减退症的TS女性中，10例（43%）甲状腺过氧化物酶抗体滴度升高，而没有甲状腺功能减退症的女性中有15例（22%）甲状腺过氧化物酶抗体滴度升高（P < 0.05），平均分布在核型45，X和嵌合体之间。高体重指数，但没有家族史或血脂，与甲状腺功能减退症TS。5年随访后，另外11例（16%）发生甲状腺功能减退，其中4例（36%）甲状腺过氧化物酶升高。总共有34名（37%）TS妇女在5年的随访后有甲状腺功能减退。自身免疫性甲状腺功能减退是常见的，TS的年发病率为3.2%。TS患者应定期检查甲状腺功能。
Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS.Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T-4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without hypothyroidism (P < 0.05), evenly distributed between the karyotype 45, X and mosaicism. A high body mass index, but not a family history or blood lipids, was associated with hypothyroidism in TS. After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase. Altogether, 34 (37%) TS women had hypothyroidism after the 5-yr follow-up.Autoimmune hypothyroidism was common, with an annual incidence of 3.2% in TS. Thyroid function should be checked regularly in TS.