Association between Healthy Eating Index-2015 and Breast Cancer Risk: A Case-Control Study.
Association between Healthy Eating Index-2015 and Breast Cancer Risk: A Case-Control Study.
复制标题
DOI：
10.31557/apjcp.2020.21.5.1363
复制
发表时间：
2020-05-01
期刊：
影响因子：
--
通讯作者：
Rashidkhani B
中科院分区：
文献类型：
--
作者：
Kord-Varkaneh H;Salehi-Sahlabadi A;Zarezade M;Rahmani J;Tan SC;Hekmatdoost A;Rashidkhani B
众所周知，饮食质量会影响癌症风险。健康饮食指数（HEI）是最常用的饮食质量指标之一。然而，HEI-2015与乳腺癌风险之间的关联尚不清楚。本研究旨在评估HEI-2015与乳腺癌风险之间的关联。 进行了一项病例对照研究，包括134例乳腺癌患者和265例无癌对照。使用经过验证的食物频率问卷（FFQ）评估膳食摄入量，并计算HEI-2015评分。Logistic回归用于推导比值比（OR），以测量HEI-2015评分与乳腺癌风险之间的关联。 HEI-2015最高四分位数的受试者患乳腺癌的几率比最低四分位数的受试者低46%（OR 0.54; 95% CI 0.30，0.98）。在调整了年龄、初潮年龄、口服避孕药使用、绝经状态、婚姻状况、体重指数、吸烟和教育水平等潜在混杂因素后，HEI-2015评分与乳腺癌低风险之间的相关性增强（OR 0.32; 95%CI 0.16，0.65）。 我们成功证明了较高的HEI-2015评分与乳腺癌风险降低有关。
Diet quality is known to influence cancer risk. The Healthy Eating Index (HEI) is one of the most frequently used measures of diet quality. However, the association between HEI-2015 and breast cancer risk is not known. The present study was undertaken to evaluate the association between HEI-2015 and breast cancer risk. A case-control study comprising 134 breast cancer patients and 265 cancer-free controls were conducted. Dietary intakes were assessed using a validated food frequency questionnaire (FFQ), from which the HEI-2015 score was calculated. Logistic regression was used to derive the odds ratios (ORs) for measuring the association between HEI-2015 scores and breast cancer risk. Subjects in the top quartile of HEI-2015 had a 46% lower chance of breast cancer compared with subjects in the bottom quartile (OR 0.54; 95% CI 0.30, 0.98). After adjustment for potential confounders such as age, age at menarche, oral contraceptive drug use, menopausal status, marital status, body mass index, smoking and education level, the association between HEI-2015 score and a lower risk of breast cancer was enhanced (OR 0.32; 95% CI 0.16, 0.65). We successfully demonstrated that a higher HEI-2015 score was associated with a reduced breast cancer risk.