ATHEROSCLEROTIC PLAQUE CAPS ARE LOCALLY WEAKENED WHEN MACROPHAGES DENSITY IS INCREASED
ATHEROSCLEROTIC PLAQUE CAPS ARE LOCALLY WEAKENED WHEN MACROPHAGES DENSITY IS INCREASED
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DOI：
10.1016/0021-9150(91)90235-u
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发表时间：
1991-03-01
期刊：
影响因子：
5.3
通讯作者：
RICHARDSON, PD
中科院分区：
文献类型：
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作者：
LENDON, CL;DAVIES, MJ;RICHARDSON, PD
对人主动脉斑块帽中由抗体EBMII鉴定的巨噬细胞的密度进行计数。 对帽组织的连续条带进行机械测试。 将一端破裂（溃疡）的主动脉斑块帽（n = 18）与完整斑块帽（n = 22）进行比较。 与完整斑块的帽相比，破裂斑块的帽显示出巨噬细胞密度的显著增加，断裂时的可延伸性增加和最大应力（每单位面积的力）降低。
The density of macrophages, identified by the antibody EBMII, in human aortic plaque caps was counted. A contiguous strip of cap tissue was tested mechanically. Aortic plaque caps which had undergone rupture (ulceration) at one end (n = 18) were compared with caps of intact plaques (n = 22). The caps of ruptured plaques showed a significant increase in macrophage density, an increased extensibility and decreased maximum stress (force per unit area) at fracture when compared with caps from intact plaques.