iHMS: a database integrating human histone modification data across developmental stages and tissues.
iHMS: a database integrating human histone modification data across developmental stages and tissues.
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iHMS：整合跨发育阶段和组织的人类组蛋白修饰数据的数据库
DOI：
10.1186/s12859-017-1461-y
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发表时间：
2017-02-11
影响因子：
3
通讯作者：
Zhou S
中科院分区：
文献类型：
--
作者：
Gan Y;Tao H;Guan J;Zhou S
背景染色质状态的差异对细胞状态的多样性至关重要。最近，不同人类发育阶段和组织的全基因组蛋白修饰图谱已经绘制出来。描述为了便于研究细胞分化过程中的表观遗传动力学和调控机制，我们开发了iHMS，这是一个整合的人类组蛋白修饰数据库，包含了跨越不同发育阶段、谱系和组织的大量组蛋白修饰图谱（ http://www.tongjidmb.com/human/index.html ).它还包括不同条件下的全基因组表达数据、参考基因注释、GC含量和CpG岛信息。通过提供直观和用户友好的查询界面，iHMS可以根据基因名称，基因组区域位置，组蛋白修饰标记和细胞类型进行全面的查询和比较分析。此外，它提供了一个高效的浏览器，允许用户可视化和比较多个全基因组的组蛋白修饰图和相关的表达谱在不同的发育阶段和tissues.ConclusioniHMS是非常有帮助的，以了解全球组蛋白修饰状态转换如何影响细胞表型在不同的发育阶段和组织在人类基因组。因此，这一广泛的组蛋白修饰目录为表观遗传和发育研究提供了重要资源。
BackgroundDifferences in chromatin states are critical to the multiplicity of cell states. Recently genome-wide histone modification maps of diverse human developmental stages and tissues have been charted.DescriptionTo facilitate the investigation of epigenetic dynamics and regulatory mechanisms in cellular differentiation processes, we developed iHMS, an integrated human histone modification database that incorporates massive histone modification maps spanning different developmental stages, lineages and tissues ( http://www.tongjidmb.com/human/index.html ). It also includes genome-wide expression data of different conditions, reference gene annotations, GC content and CpG island information. By providing an intuitive and user-friendly query interface, iHMS enables comprehensive query and comparative analysis based on gene names, genomic region locations, histone modification marks and cell types. Moreover, it offers an efficient browser that allows users to visualize and compare multiple genome-wide histone modification maps and related expression profiles across different developmental stages and tissues.ConclusioniHMS is of great helpfulness to understand how global histone modification state transitions impact cellular phenotypes across different developmental stages and tissues in the human genome. This extensive catalog of histone modification states thus presents an important resource for epigenetic and developmental studies.