Using molecular markers in sputum for the early detection of lung cancer: A review
Using molecular markers in sputum for the early detection of lung cancer: A review
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DOI：
10.1016/j.lungcan.2004.07.996
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发表时间：
2004-08-01
期刊：
影响因子：
5.3
通讯作者：
Hirsch, FR
中科院分区：
文献类型：
--
作者：
Kennedy, TC;Hirsch, FR
最近在鉴定痰中潜在的分子标志物方面取得了令人兴奋的进展，这些分子标志物可能很快就会准备好进行验证试验，以表明肺癌，特别是中央呼吸道鳞状细胞肺癌的高风险。希望一组生物标记物能够。与传统的细胞病理学相比，它具有更高的敏感度、特异度和足够的准备时间，因此有理由进行支气管腔内评估和局部治疗，以帮助降低高危患者的肺癌死亡率。(C)2004年爱思唯尔科学有限公司。
Recent exciting advances have been made in identifying potential molecular markers in sputum which may soon be ready for validation trials to indicate high risk for lung cancer, especially central airway squamous cell lung cancer. Hopefully, a set of biomarkers will. be identified with higher sensitivity, specificity, and enough lead-time compared to traditional cytopathology to justify endobronchial evaluation and local therapy to help reduce lung-cancer mortality in high-risk patients. (C) 2004 Elsevier Science Ltd.