Physical frailty and body composition in obese elderly men and women
Physical frailty and body composition in obese elderly men and women
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DOI：
10.1038/oby.2004.111
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发表时间：
2004-06-01
期刊：
影响因子：
--
通讯作者：
Klein, S
中科院分区：
文献类型：
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作者：
Villareal, DT;Banks, M;Klein, S
目的：探讨社区肥胖老年人的身体虚弱状况及其与身体成分、身体机能和生活质量的关系。研究方法和步骤：对52名社区肥胖老年人、52名非肥胖体弱者和52名非肥胖非体弱者进行年龄和性别匹配的研究。采用体能测试、运动负荷测试、下肢力量、步速、静态和动态平衡、功能状态问卷和健康相关生活质量问卷(简称医学结果简表)对功能状态的主客观指标进行评估。结果：在OE受试者中，96%的受试者符合我们的轻至中度脆弱的标准。与非肥胖组相比，OE组和非肥胖组在体能测试、最大有氧功率和机能状况问卷中得分较低且相近，在力量、步行速度、平衡性和健康相关生活质量方面表现出类似的损害。尽管绝对脱脂质量(FFM)较大，但OE组的体重占FFM的百分比和肌肉质量低于其他两组。讨论：易丧失独立性的身体虚弱在社区生活的OE男性和女性中普遍存在。OE受试者的身体虚弱与FFM百分比低、肌肉质量差和生活质量下降有关。这些发现表明，除了改善与肥胖相关的医学并发症外，减肥治疗对OE患者改善身体功能可能特别重要。
Objective: To evaluate the prevalence of frailty and interrelationships among body composition, physical function, and quality of life in community-dwelling obese elderly (OE) persons.Research Methods and Procedures: Fifty-two OE, 52 nonobese frail, and 52 Donobese nonfrail subjects, matched for age and sex, were studied. Subjective and objective measures of functional status were evaluated by using the physical performance test, exercise stress test, lower extremity (LE) strength, gait speed, static and dynamic balance, functional status questionnaires, and health-related quality-of-life questionnaire (Medical Outcomes Short Form). Body composition was evaluated by using DXA, and muscle quality was evaluated by determining the ratio of LE strength to LE lean mass.Results: Among OE subjects, 96% met our standard criteria for mild to moderate frailty. Compared with the nonobese nonfrail group, the OE and nonobese frail groups had lower and similar scores in physical performance test, peak aerobic power, and functional status questionnaire, and exhibited similar impairments in strength, walking speed, balance, and health-related quality of life. Although absolute fat-free mass (FFM) was greater, the percentage body weight as FFM and muscle quality was lower in the OE group than in the other two groups.Discussion: Physical frailty, which predisposes to loss of independence, is common in community-living OE men and women. Physical frailty in OE subjects was associated with low percentage FFM, poor muscle quality, and decreased quality of life. These findings suggest that weight loss therapy may be particularly important in OE persons to improve physical function, in addition to improving the medical complications associated with obesity.