Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment
Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment
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DOI：
10.1016/j.euroneuro.2005.09.004
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发表时间：
2006-05-01
影响因子：
5.6
通讯作者：
Kennedy, JL
中科院分区：
文献类型：
--
作者：
Hwang, R;Shinkai, T;Kennedy, JL
目的：探讨12多巴胺D2基因变异和定量措施的积极和消极的症状反应后，氯氮平治疗在两个治疗难治性或不耐受人群（白人和非洲裔美国人）之间的关系。实验程序：受试者包括97名白人和35名非裔美国人DSM-III-R或DSM-IV精神分裂症患者，并通过5 '-核酸外切酶荧光测定进行基因分型。采用方差分析比较基因型、等位基因+/-和单体型组在简明精神病评定量表（BPRS）总体、阳性（BPOS）和阴性症状分量表（BNEG）上的差异。结果：在高加索人中，没有发现任何个体多态性或单倍型的显着关联。在非裔美国人中，TaqIB B2（T）等位基因和rs 1125394等位基因1（A）以及包含这两个等位基因的双标记单倍型与总体BPRS和BPOS反应的改善相关。结论：氯氮平反应的变异性仍未完全了解，可能涉及多种因素。这项研究表明，D2受体基因变异可能是这些因素之一。(c)2005年Elsevier B. V.和ECNP。All rights reserved.
Objective: Explore relationships between 12 dopamine D2 gene variants and quantitative measures of positive and negative symptom response following clozapine treatment in two treatment refractory or intolerant populations (Caucasian and African-American). Experimental procedures: Subjects included 97 Caucasian and 35 African-American DSM-III-R or DSM-IV schizophrenics and were genotyped by 5 '-exonuclease fluorescence assays. Genotype, allele +/- and haptotype groups were compared on Brief Psychiatric Rating Scale (BPRS) overall, positive (BPOS) and negative symptom subscales (BNEG) using analysis of variance. Results: In Caucasians, no significant associations were found for any individual polymorphisms or haplotypes. In African-Americans, the TaqIB B2 (T) allele and rs1125394 allele 1 (A), and a two-marker haplotype containing these two alleles were associated with improvement in overall BPRS and BPOS response. Conclusions: Variability in clozapine response is still not fully understood and likely involves multiple factors. This study suggests that D2 receptor gene variants may be among such factors. (c) 2005 Elsevier B.V. and ECNP. All rights reserved.