Fertility and menopausal outcomes in young breast cancer survivors
Fertility and menopausal outcomes in young breast cancer survivors
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DOI：
10.3816/cbc.2008.n.004
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发表时间：
2008-02-01
影响因子：
3.1
通讯作者：
Winer, Eric P.
中科院分区：
文献类型：
--
作者：
Partridge, Ann H.;Gelber, Shari;Winer, Eric P.
背景：在乳腺癌治疗后，许多年轻女性对生孩子感兴趣。关于年轻乳腺癌幸存者的实际生育率和绝经结局的数据很少。我们与青年生存联盟（Young Survival Coalition）合作，对年轻乳腺癌幸存者的这些结果进行了评估，青年生存联盟是一个年轻乳腺癌女性的国际倡导组织。患者和方法：通过电子邮件向所有登记的青年生存联盟幸存者成员发送了一个关于早期乳腺癌妇女生育问题调查的链接; 440名完成调查的妇女有资格参加这项分析。调查受访者的平均诊断时间为2.8年。乳腺癌诊断的平均年龄为32.6岁。结果如下：在该队列的440名女性中，247名女性（56%）回忆说，她们在诊断时希望将来怀孕，43名女性（10%）采取措施保持生育能力。共有384名妇女（87%）接受了化疗。共有295名妇女（67%）报告说，她们仍然处于绝经前，另有33名妇女（8%）在调查时正在接受卵巢抑制治疗。自诊断以来，70名妇女（16%）怀孕≥ 1次; 40名妇女（9%）有≥ 1次活产。在247名报告在诊断时希望未来怀孕的妇女中，有59名（24%）已经怀孕。在60名报告自诊断以来试图怀孕的妇女中，34名（57%）成功。结论：大多数年轻女性在接受乳腺癌治疗（包括化疗）后仍处于绝经前。在这一系列的妇女中，怀孕的比例相对较小;然而，自诊断以来的中位时间相对较短。
Background: Following treatment for breast cancer, many young women are interested in having a child. There are few data available regarding actual fertility and menopausal outcomes in young breast cancer survivors. We evaluated these outcomes among young breast cancer survivors in collaboration with the Young Survival Coalition, an international advocacy group for young women with breast cancer. Patients and Methods: All registered Young Survival Coalition survivor members were sent a link to the survey about fertility issues for women with early-stage breast cancer via e-mail; 440 women who completed the survey were eligible for this analysis. Survey respondents were a median of 2.8 years from diagnosis. Mean age at breast cancer diagnosis was 32.6 years. Results: Of the 440 women in this cohort, 247 women (56%) recalled that they had desired a future pregnancy at diagnosis, and 43 women (10%) took steps to preserve fertility. A total of 384 women (87%) received chemotherapy. A total of 295 women (67%) reported that they remained premenopausal, and an additional 33 women (8%) were receiving ovarian suppression therapy at the time of the survey. Since diagnosis, 70 women (16%) had been pregnant >= 1 time; 40 women (9%) had >= 1 live birth. Out of the 247 women who reported wanting a future pregnancy at diagnosis, 59 (24%) had become pregnant. Of the 60 women who reported having tried to become pregnant since diagnosis, 34 (57%) were successful. Conclusion: Most young women remain premenopausal after breast cancer treatment, including chemotherapy. A relatively small percentage of women in this series had become pregnant; however, the median time since diagnosis was relatively short.