Activation of apoptosis pathways by anticancer treatment
Activation of apoptosis pathways by anticancer treatment
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DOI：
10.1016/s0378-4274(99)00252-0
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发表时间：
2000-03-15
影响因子：
3.5
通讯作者：
Debatin, KM
中科院分区：
文献类型：
--
作者：
Debatin, KM
包括急性白血病在内的恶性肿瘤的化学治疗主要基于经验数据和临床经验。近年来，抗癌药物诱导靶细胞凋亡的作用越来越明显。药物诱导的细胞凋亡途径的激活似乎包括死亡受体系统的平行或顺序激活，最重要的是，线粒体功能的变化伴随着致凋亡因子的释放，导致下游半胱天冬酶的激活。药物诱导的细胞凋亡和效应器半胱天冬酶激活的关键因素的确定无疑将为恶性肿瘤和白血病的化学敏感性或化学耐药性的分子决定因素提供新的见解。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Chemotherapy of malignant tumors including acute leukemias is largely based on empirical data and clinical experience. In the recent years it has become clear that anticancer drugs induce apoptosis in target cells. Drug-induced activation of apoptosis pathways appears to include parallel or sequential activation of death receptor systems and, most importantly, changes in mitochondrial function with concomitant release of apoptogenic factors leading to activation of downstream caspases. The identification of the critical elements of drug-induced apoptosis and activation of effector caspases will certainly provide new insights into the molecular determinants of chemosensitivity or chemoresistance of malignant tumors and leukemias. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.