Health-related quality of life results in pathologic stage C prostate cancer from a southwest oncology group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy
Health-related quality of life results in pathologic stage C prostate cancer from a southwest oncology group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy
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DOI：
10.1200/jco.2006.10.4505
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发表时间：
2008-01-01
影响因子：
45.3
通讯作者：
Crawford, E. David
中科院分区：
文献类型：
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作者：
Moinpour, Carol M.;Hayden, Katherine A.;Crawford, E. David
目的比较短期和长期效果的辅助治疗与观察手术后的健康相关的生活质量（HRQL）的前列腺癌patients.Patients和方法西南肿瘤组（SWOG）组间试验比较根治性前列腺切除术（RP）加观察与RP加辅助放射治疗（RT）。425例治疗性试验患者中有217例符合条件并登记参加HRQL研究。患者在基线、第6周、第6个月和5年每年完成SWOG生活质量问卷（情感、身体、社会和角色功能;一般症状状态;治疗/疾病特异性症状;和总体HRQL [GHRQL]）。预先设定的结果是三种泌尿生殖系统症状（肠功能压痛、尿频和勃起功能障碍[艾德]）以及身体和情感功能的测量。基线scores.Results接受辅助RT的患者报告更差的肠功能（通过约2年）和更差的泌尿功能。ED无统计学显著性差异。RP+RT组的GHRQL最初较差，但随时间推移改善，并且在周期结束时优于RP单药组报告的GHRQL（治疗组x时间相互作用，P = .0004）。症状的困扰是显着恶化的RP+RT手臂相比，RP单独的手臂，但治疗手臂没有不同的其他一般措施HRQL.Conclusion除了RT手术导致更频繁的排尿，以及早期报告更多的肠功能障碍，虽然肠功能差异消失了5年的时间。RT的添加对ED没有负面影响。
Purpose To compare short- and long-term effects of adjuvant treatment versus observation after surgery on health-related quality of life (HRQL) of prostate cancer patients.Patients and Methods The Southwest Oncology Group (SWOG) intergroup trial compared radical prostatectomy (RP) plus observation versus RP plus adjuvant radiation therapy (RT). Two-hundred seventeen of 425 therapeutic trial patients were eligible and registered to the HRQL study. Patients completed the SWOG Quality of Life Questionnaire (emotional, physical, social, and role function; general symptom status; treatment/disease-specific symptoms; and global HRQL [GHRQL]) at baseline, 6 weeks, 6 months, and annually for 5 years. Prespecified outcomes were three genitourinary symptoms (bowel function tenderness, frequent urination, and erectile dysfunction [ED]) and measures of physical and emotional function. Adjustments were made for the baseline score.Results Patients receiving adjuvant RT reported worse bowel function (through approximately 2 years) and worse urinary function. There were no statistically significant differences for ED. GHRQL was initially worse for the RP+RT arm but improved over time and was better at the end of the period than the GHRQL reported for RP alone (treatment arm x time interaction, P = .0004). Symptom distress was significantly worse for the RP+RT arm compared with the RP alone arm, but the treatment arms did not differ with respect to other general measures of HRQL.Conclusion The addition of RT to surgery resulted in more frequent urination, as well as early report of more bowel dysfunction, although bowel function differences disappeared over the 5-year period. The addition of RT did not negatively impact ED.