About the Guidelines for Outpatient Parenteral Antimicrobial Therapy
About the Guidelines for Outpatient Parenteral Antimicrobial Therapy
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关于门诊肠外抗菌治疗指南
DOI：
10.1086/425507
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发表时间：
2004
影响因子：
11.8
通讯作者：
E. Aramendi
中科院分区：
文献类型：
--
作者：
M. Sánchez;M. Sampedro;C. G. Orbáiz;José A. Carrera Macazaga;E. Aramendi
先生，我们非常感兴趣地阅读了Tice等人的文章，该文章提出了门诊肠道外抗菌治疗的指导方针。因为我们认为他们文章的主要目的是为常规使用这种疗法的专业人员提供信息，所以我们想提供一些相关的事实和额外的信息。我们关注的是，在关于抗菌药物选择和给药的讨论中，没有提到一些抗菌药物的使用，如哌拉西林-他唑巴坦或替柯普兰。哌拉西林-他唑巴坦是一种具有广泛体外活性谱的b-内酰胺，与亚胺培南相当，比头孢他啶更大。此外，室温下在盐水溶液中稳定24小时，在5C冷藏时稳定7天。由于其抗菌谱、单药治疗和稳定性，哌拉西林-他唑巴坦是一种很好的抗生素，用于治疗怀疑有多种微生物（厌氧和/或好氧）感染。在门诊治疗中表现出不同的效果[2,3]。Teicoplanin是一种具有抗菌活性的糖肽，与万古霉素非常相似，但比后者有优势。对于替柯planin，每天1剂是可能的，在某些情况下，每72小时1剂是可能的[4-5]。替柯planin也可以通过肌肉注射给药，它不需要像万古霉素那样长时间的输注，而且使用它几乎没有发生“红人综合征”的风险。也许teicoplanin在美国很少使用
Sir—We have read with great interest the article by Tice et al.[1], which presents guidelines for outpatient parenteral antimicrobial therapy. Because we believe that the main goal of their article is to provide information to professionals who routinely administer this therapy, we would like to contribute some related facts and additional information. It has concerned us that in discussion about antimicrobial selection and administration, no reference has been made to the use of some antimicrobials, such as piperacillin-tazobactam or teicoplanin. Piperacillin-tazobactam is a b-lactam with a wide in vitro spectrum of activity, comparable to that of imipenem and greater than that of ceftazidime. Furthermore, it is stable in saline solution for 24 h at room temperature and for 7 days when refrigerated at 5C. Because of its antimicrobial spectrum, its use in monotherapy, and its stability, piperacillin-tazobactam is a good antibiotic for treating infections in which multiple organisms, anaerobic and/or aerobic, are suspected. It demonstrates different results in outpatient treatment [2, 3]. Teicoplanin is a glycopeptide with antimicrobial activity that is very similar to that of vancomycin but with advantages over the latter. With teicoplanin, 1 dose per day is possible, and in some cases, 1 dose per 72 h is possible [4–5]. Teicoplanin can also be administered by the intramuscular route, it does not require as long an infusion time as does vancomycin, and use of it carries little risk for developing “red man syndrome.” Perhaps there is little use of teicoplanin in the United