A newly developed intra-operative gamma camera: performance characteristics in a laboratory phantom study
A newly developed intra-operative gamma camera: performance characteristics in a laboratory phantom study
复制标题
DOI：
10.1007/s00259-005-1823-y
复制
发表时间：
2005-10-01
影响因子：
9.1
通讯作者：
Hashmonai, M
中科院分区：
文献类型：
--
作者：
Kopelman, D;Blevis, I;Hashmonai, M
目的：放射引导手术依赖于术中对放射标记组织的检测。目前，这是通过能够提供音调信号的手动工具完成的，这取决于与探针相关的放射源的接近程度和方向。放射性标记组织的视觉图像的优势是公认的，但术中获得这种图像的令人满意的方法尚不可用。本研究的目的是检查一种新开发的术中伽马相机的性能，它足够紧凑，可以作为一种手动工具，能够产生源场的视觉图像。方法：研究在实验室中进行，其中包括水浴和以不同配置放置在水浴中的填充Tc-99m （1-5 μ Ci/cc）的小空心球体（1-2 cm内径）。为了进行比较，也有研究使用标准的术中伽马探头，其他研究使用标准的单头高分辨率伽马相机。结果：与伽玛探头相比，术中相机具有更强的分辨小、深、弱局部辐射源的能力。通过从不同角度获取图像，它可以对多个放射源进行3D了解。它在一个放射性标记的“热”球体内检测到“冷”缺陷。它与标准伽玛相机的识别方法类似，识别出位于“更热”辐射源附近的弱辐射源，并在放射性背景下识别出局部辐射源。结论：本研究所测试的相机具有较高的成像潜力，有望为临床提供优势。
Purpose: Radioguided surgery depends on the intra-operative detection of radiolabelled tissues. This is currently accomplished with hand tools capable of providing a tone signal, depending on the proximity and direction of a radioactive source in relation to the probe. The advantages of visual images of radiolabelled tissues are well recognised, but satisfactory means of acquiring such images intra-operatively are not yet available. The goal of this study was to examine the performance of a newly developed intra-operative gamma camera, compact enough to be a hand tool and capable of yielding a visual image of the source field.Methods: The study was performed in the laboratory with a phantom consisting of a water bath and small hollow spheres (1-2 cm in internal diameter) filled with Tc-99m (1-5 mu Ci/cc), placed in different configurations within the bath. For comparison, studies were also performed using a standard intra-operative gamma probe, and others using a standard single-head high-resolution gamma camera.Results: Compared with the gamma probe, the intra-operative camera was found to possess a superior ability to distinguish small, deep and weakly localised radioactivity sources from background. By acquiring images from different angles, it allowed a 3D understanding of multiple radioactive sources. It detected "cold" defects within a "hot" radiolabelled sphere. It discriminated a weak source located near a much "hotter" radioactivity source, similar to discrimination with the standard gamma camera, and discerned localised sources against a background of radioactivity.Conclusion: It is anticipated that the high imaging potential of the camera tested in this study will offer clinical advantages.