Hepatitis E Virus Genome Structure and Replication Strategy
Hepatitis E Virus Genome Structure and Replication Strategy
复制标题
DOI：
10.1101/cshperspect.a031724
复制
发表时间：
2019-01-01
影响因子：
5.4
通讯作者：
Meng, Xiang-Jin
中科院分区：
文献类型：
--
作者：
Kenney, Scott P.;Meng, Xiang-Jin
戊型肝炎病毒（HEV）具有其他正链RNA病毒的许多特征，但也增加了HEV特异性的细微差别，使其病毒-宿主相互作用独特。缓慢的病毒复制动力学和苛刻的生长条件，加上历史上缺乏有效的细胞培养系统来繁殖病毒，在我们对其结构和复制周期的理解上留下了许多空白。最近在培养HEV选定菌株和解决病毒衣壳三维结构方面的进展正在填补知识空白，但HEV仍然是一种研究非常不足的病原体。HEV生命周期的许多步骤和HEV发病机制的许多方面仍然未知，例如决定跨物种感染的宿主和病毒因素，宿主细胞上的HEV特异性受体，决定HEV慢性性和在肝外部位复制能力的因素，以及调节开放阅读框1 （ORF1）非结构多蛋白加工的因素。
Hepatitis E virus (HEV) possesses many of the features of other positive-stranded RNA viruses but also adds HEV-specific nuances, making its virus-host interactions unique. Slow virus replication kinetics and fastidious growth conditions, coupled with the historical lack of an efficient cell culture system to propagate the virus, have left many gaps in our understanding of its structure and replication cycle. Recent advances in culturing selected strains of HEV and resolving the 3D structure of the viral capsid are filling in knowledge gaps, but HEV remains an extremely understudied pathogen. Many steps in the HEV life cycle and many aspects of HEV pathogenesis remain unknown, such as the host and viral factors that determine cross-species infection, the HEV-specific receptor(s) on host cells, what determines HEV chronicity and the ability to replicate in extrahepatic sites, and what regulates processing of the open reading frame 1 (ORF1) nonstructural polyprotein.