HEAT-LOSS REACTION TO CAPSAICIN THROUGH A PERIPHERAL SITE OF ACTION
HEAT-LOSS REACTION TO CAPSAICIN THROUGH A PERIPHERAL SITE OF ACTION
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DOI：
10.1111/j.1476-5381.1983.tb10009.x
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发表时间：
1983-01-01
影响因子：
7.3
通讯作者：
LEMBECK, F
中科院分区：
文献类型：
--
作者：
DONNERER, J;LEMBECK, F
静脉内注射15 μ g辣椒素使清醒大鼠的尾部皮肤和爪垫温度升高，结肠温度下降。这些反应反映了增加的热耗散。静脉注射辣椒素引起的皮肤温度的增加是不存在的小直径初级传入神经元的功能受损时，辣椒素治疗的大鼠作为新生儿。辣椒素静脉注射显然主要通过刺激外周热感受器来触发体温调节反应。通过对后肢神经局部应用辣椒素，并通过其慢性去神经支配，通过用酚苄明和乙啶治疗，获得了交感血管收缩张力的反射性撤回介导对静脉辣椒素的热损失反应的证据。
The i.v. injection of 15 .mu.g capsaicin produced an increase in the temperature of tail skin and paw pad and a fall in the colon temperature in conscious rats. These reactions reflect increased heat dissipation. The increase in skin temperature induced by i.v. capsaicin was absent when the function of small diameter primary afferent neurons was impaired by treatment of the rats with capsaicin as neonates. Capsaicin i.v. apparently triggered the thermoregulatory response predominantly by stimulation of peripheral heat receptors. By means of local application of capsaicin to the nerves of the hind leg and by their chronic denervation, by treatment with phenoxybenzamine and guanethidine, evidence was obtained that reflex withdrawal of sympathetic vasoconstrictor tone mediates the heat loss reaction to i.v. capsaicin.