Dengue is still an imported disease in China: A case study in Guangzhou
Dengue is still an imported disease in China: A case study in Guangzhou
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登革热在中国仍属于输入性疾病：以广州为例
DOI：
10.1016/j.meegid.2015.03.005
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发表时间：
2015-06-01
影响因子：
3.2
通讯作者：
Liu, Qiyong
中科院分区：
文献类型：
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作者：
Sang, Shaowei;Chen, Bin;Liu, Qiyong
登革病毒及其四种血清型（DENV 1-4）每年感染全球约3.9亿人，大多数病例发生在热带和亚热带地区。由于登革病毒从流行区的反复传入和适宜的气候条件，近几十年来许多地区已从低流行转变为高流行。自1978年第一次登革热爆发以来，了解中国近40年来的现状至关重要。为了解我国登革热是否为地方性流行，为制定我国登革热防控策略提供依据，结合疾病通报系统、系统发育分析和地理分布学分析，结果表明，我国广州地区登革热4种血清型均有检出，以DENV 1-2型为主。最大似然树分析结果表明，除2002年和2003年的病毒聚在一起外，广州地区的病毒分布在不同的分支中。广州与东南亚之间存在着相互介绍的关系。病毒输入主要来自东南亚，广州暴发疫情的传染源主要来自泰国、印度尼西亚和菲律宾，提示我国登革热仍为输入性疾病，存在本地化的可能性。(C)2015爱思唯尔B. V.保留所有权利。
Dengue virus and its four serotypes (DENV 1-4) infect approximately 390 million people worldwide each year, with most cases in tropical and subtropical regions. Because of repeated introduction of DENV from epidemic regions and suitable weather conditions, many regions have shifted from hypo-endemicity to hyper-endemicity over recent decades. Since the first dengue outbreak in 1978, it is crucial to understand the current situation in China over nearly 40 years. The purpose of the study was to examine whether dengue in China was endemic or not, which is essential for relevant dengue control and prevention strategy implementation in China.The study, combining epidemiological characteristics of dengue from the disease notification system, phylogenetic and phylogeographic analyses, showed that all four serotypes had been detected in Guangzhou, China, which was dominated by DENV 1-2. The Maximum Likelihood tree analytic results showed that the virus detected in Guangzhou localized in different clades, except of virus of 2002 and 2003 clustered together. There existed the mutual introductions between Guangzhou and Southeast Asia. Most of the viruses were imported from Southeast Asia and the sources of outbreaks in Guangzhou mainly originated from Thailand, Indonesia, and the Philippines.The study indicates that dengue in China still remains as an imported disease, with the possibility of localization. (C) 2015 Elsevier B.V. All rights reserved.