Cycling Regimen Induces Spinal Circuitry Plasticity and Improves Leg Muscle Coordination in Individuals With Spinocerebellar Ataxia
Cycling Regimen Induces Spinal Circuitry Plasticity and Improves Leg Muscle Coordination in Individuals With Spinocerebellar Ataxia
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DOI：
10.1016/j.apmr.2015.01.021
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发表时间：
2015-06-01
影响因子：
4.3
通讯作者：
Hsu, Miao-Ju
中科院分区：
文献类型：
--
作者：
Chang, Ya-Ju;Chou, Ching-Chieh;Hsu, Miao-Ju
Objectives: To compare the reciprocal control of agonist and antagonist muscles in individuals with and without spinocerebellar ataxia (SCA) and to evaluate the effect of a 4-week leg cycling regimen on functional coordination and reciprocal control of agonist and antagonist muscles in patients with SCA.Design: Randomized controlled trial with repeated measures.Setting: Research laboratory in a general hospital.Participants: Individuals with SCA (n=20) and without SCA (n=20).Interventions: A single 15-minute session of leg cycling and a 4-week cycling regimen.Main Outcome Measures: Individuals with SCA (n=20) and without SCA (n=20) underwent disynaptic reciprocal inhibition and D1 inhibition tests of the soleus muscles before and after a single 15-minute cycling session. Individuals with SCA were randomly assigned to either participate in 4 weeks of cycling training (n=10) or to receive no training (n=10). The disynaptic reciprocal inhibition and D1 inhibition and International Cooperative Ataxia Rating Scale (ICARS) scores were evaluated in both groups after 4 weeks.Results: Individuals with SCA showed abnormally strong resting values of disynaptic reciprocal inhibition and D1 inhibition (P
