Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
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DOI：
10.1111/jth.14768
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发表时间：
2020-03-13
影响因子：
10.4
通讯作者：
Sun, Ziyong
中科院分区：
文献类型：
--
作者：
Tang, Ning;Li, Dengju;Sun, Ziyong
目的探讨新型冠状病毒肺炎（NCP）患者的凝血功能特点。方法回顾性分析同济医院183例确诊NCP患者的常规凝血功能检查结果及预后。结果183例NCP患者的总死亡率为11.5%（183/183），其中21例患者的凝血功能明显异常，1例患者的凝血功能明显下降。与入院时的存活者相比，死亡者的D-二聚体和纤维蛋白降解产物（FDP）水平显著升高，凝血酶原时间和活化部分凝血活酶时间延长（P < .05）; 71.4%的死亡者和0.6%的存活者在住院期间符合弥散性血管内凝血的标准。尤其是显著升高的D-二聚体和FDP在NCP死亡中很常见。
Background In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.Objectives To describe the coagulation feature of patients with NCP.Methods Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.Results The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.Conclusions The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.