Clinical features and associated psychopathology in a Tourette syndrome cohort
Clinical features and associated psychopathology in a Tourette syndrome cohort
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DOI：
10.1046/j.1600-0404.2003.00228.x
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发表时间：
2004-04-01
影响因子：
3.5
通讯作者：
Robertson, M
中科院分区：
文献类型：
--
作者：
Eapen, V;Fox-Hiley, P;Robertson, M
目的：本研究详细探讨了英国一家诊所91名连续成年TS受试者的抽动障碍、相关临床变量和精神病理学之间的关联。方法：来自一家专门的抽动秽语症诊所的符合DSM-III标准的抽动秽语综合征患者，使用抽动秽语综合征和其他精神病理学的标准化评定量表进行评估。结果-我们队列中的男女比例为1.8：1。明显更多的男性有较早的发病年龄TS和出生并发症的历史。强迫行为与注意缺陷多动障碍、自伤行为呈正相关。关于成人精神病理学，主成分因子分析产生了两个因素，“强迫症”和“焦虑/抑郁”，占72%的方差。结论-我们的研究结果支持高发生率的焦虑，抑郁和强迫症的成年TS科目。
Objective - This study explored in detail the association between tic symptomatology, related clinical variables, and psychopathology in 91 consecutive adult TS subjects from a UK clinic. Methods - Consecutive patients from a specialized Tourette clinic who met the DSM-III criteria for TS were evaluated using standardized rating scales for Tourette syndrome and other psychopathology. Results - The male female ratio in our cohort was 1.8:1. Significantly more males had an earlier age at onset of TS and history of birth complications. Obsessive compulsive behaviors in the patient was positively correlated with presence of attention deficit hyperactivity disorder and self-injurious behaviors. With regard to adult psychopathology, principal components factor analysis yielded two factors, 'obsessionality' and 'anxiety/depression', which accounted for 72% of the variance. Conclusion - Our results support the high occurrence of anxiety, depression and obsessionality in adult TS subjects.