Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant
Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant
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DOI：
10.1016/j.bbrc.2007.11.069
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发表时间：
2008-01-25
影响因子：
3.1
通讯作者：
Ukomadu, Chinweike
中科院分区：
文献类型：
--
作者：
Liu, Zhilin;Ukomadu, Chinweike
纤维蛋白原样蛋白1(FGL1)是一种肝细胞来源的蛋白，在部分肝切除后再生的啮齿动物肝脏中表达上调。它被认为是一种促进肝细胞增殖的有丝分裂原。在这项研究中，我们证明了重组人IL-6诱导Hep G2细胞FGL1表达的模式类似于急性时相反应物。皮下注射松节油诱导大鼠急性炎症后，血清FGL1水平也升高。虽然，最近的一份报告表明，FGL1几乎完全与纤维蛋白基质有关，但我们在这里报告，大约20%的血浆FGL1仍然是游离的。IL-6在体外对FGL1水平的升高和松节油注射后对FGL1的诱导，提示它是一种急性时相反应物。它在血液中以结合形式和游离形式存在，也意味着它在再生过程中对肝细胞所起的自分泌作用之外的生物学作用。(C)2007 Elsevier Inc.保留所有权利。
Fibrinogen-like protein 1 (FGL1) is a hepatocyte derived protein that is upregulated in regenerating rodent livers following partial hepatectomy. It has been implicated as a mitogen for liver cell proliferation. In this study, we show that recombinant human IL-6 induces FGL1 expression in Hep G2 cells in a pattern similar to those of acute phase reactants. Following induction of acute inflammation in rats by subcutaneous injection of turpentine oil, serum FGL1 levels are also enhanced. Although, a recent report suggests that FGL1 associates almost exclusively with the fibrin matrix, we report here that approximately 20% of the total plasma FGL1 remains free. The enhancement of FGL1 levels in vitro by IL-6 and its induction after turpentine oil injection suggest that it is an acute phase reactant. Its presence in bound and free forms in the blood also implies biological roles that extend beyond the proposed autocrine effect it has on hepatocytes during regeneration. (c) 2007 Elsevier Inc. All rights reserved.